Advances in Food Toxicology and Human Health Risk Assessment

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Analytical Methods".

Deadline for manuscript submissions: 15 October 2026 | Viewed by 1187

Special Issue Editors


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Guest Editor
Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia
Interests: public health; environmental health; health risk assessment; occupational health; food safety; food toxicology
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece
Interests: biomonitoring; pesticide exposure; analytical toxicology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ensuring the safety of our food supply remains one of the most critical challenges in modern public health, given growing environmental concerns, the emergence of novel contaminants, and increasing insights into their health effects. In recent years, the presence of contaminants such as pesticide residues, mycotoxins, heavy metals, and emerging pollutants in food has raised significant public health concerns worldwide. Regulatory frameworks are continually updated in response to new toxicological evidence, while risk assessment methodologies are evolving to better reflect real-world human exposure scenarios. In this context, advances in food toxicology play a crucial role in informing policy decisions and protecting consumers. Food toxicology is now a fundamental discipline for identifying, characterising, and assessing the health risks associated with a wide range of hazardous substances present in food. This Special Issue welcomes contributions addressing current challenges and advances in food toxicology and human health risk assessment, including original research articles and reviews on the detection, quantification, and toxicological characterisation of both naturally occurring toxins and environmental contaminants in food. Studies using cumulative and aggregate risk assessment frameworks to explore the combined effects of multiple substances on human dietary exposure are also welcome, as are contributions that integrate toxicological, epidemiological, and regulatory perspectives to strengthen the evidence base for public health strategies and food safety policies. We look forward to receiving submissions that enhance our understanding of food-related health risks and support the development of more effective food safety policies.

Dr. Nika Pavlović
Dr. Matthaios P. Kavvalakis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food toxicology
  • human health risk assessment
  • food contaminants
  • dietary exposure
  • pesticide residues
  • mycotoxins
  • heavy metals
  • emerging contaminants
  • cumulative risk assessment
  • exposure assessment
  • food safety regulation
  • public health

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Published Papers (1 paper)

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Review

24 pages, 4039 KB  
Review
Simultaneous Determination of Bisphenol A and Its Analogues in Food Matrixes: Cumulative Exposure Assessment Following New Regulatory Restrictions—A Systematic Review
by Nika Lovrincevic Pavlovic, Ivan Miskulin, Ivana Kotromanovic Simic, Lea Dumic, Darko Kotromanovic and Maja Miskulin
Foods 2026, 15(6), 1104; https://doi.org/10.3390/foods15061104 - 21 Mar 2026
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Abstract
Recent scientific evidence confirms that there is no safe threshold for bisphenol A intake, prompting strict regulatory actions and new prohibitions in the European Union. As a result, bisphenol A has increasingly been replaced by other analogues that are also toxic but less [...] Read more.
Recent scientific evidence confirms that there is no safe threshold for bisphenol A intake, prompting strict regulatory actions and new prohibitions in the European Union. As a result, bisphenol A has increasingly been replaced by other analogues that are also toxic but less regulated and insufficiently studied, posing a new risk to human health due to cumulative exposure. Since food is the primary source of exposure to these compounds, this review aimed to evaluate the most appropriate existing chromatographic methods for their determination under newly introduced near-zero tolerance limits, as well as to assess current cumulative dietary exposure and associated health risks. A systematic literature search was conducted in major scientific databases and relevant regulatory sources covering the period from 2015 to 2025, following PRISMA guidelines. Of the 489 identified publications, 22 met the eligibility criteria for full-text analysis. The findings indicate a clear methodological shift towards simultaneous quantification of multiple bisphenol analogues, with LC-MS/MS emerging as the dominant and most robust analytical technique. Dietary exposure to bisphenol A is expected to decline due to stricter regulations; however, this may trigger a rise in the use of its structural analogues as alternatives. Exposure assessments indicate that combined dietary intake of bisphenol A and its analogues can result in a Hazard Index exceeding 1, primarily due to the substantially reduced Tolerable Daily Intake for bisphenol A. This highlights the need for continuous monitoring under stricter regulatory frameworks. Full article
(This article belongs to the Special Issue Advances in Food Toxicology and Human Health Risk Assessment)
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