Bioactive Compounds in Fruits and Vegetables: Processing, Bioavailability and Functional Properties

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 1691

Special Issue Editors


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Guest Editor
College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
Interests: food nutrition; natural active substances; food biotechnology

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Guest Editor
College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China
Interests: structure-activity relationship of food nutrients

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Guest Editor Assistant
College of Life Sciences, Fujian Normal University, Fuzhou 350117, China
Interests: natural products; microbiology; mushrooms

Special Issue Information

Dear Colleagues,

Fruits and vegetables are being promoted as a component of healthy dietary patterns and disease management, providing a rich source of vitamins, dietary fiber, and various other nutrients. Currently, bioactive compounds from fruits and vegetables, such as polyphenols, carotenoids, and flavonoids, have drawn significant attention for their potential role in preventing chronic diseases and promoting overall well-being. However, understanding how to effectively extract, enhance, and utilize these compounds remains a critical challenge. We still want to know: What are the most efficient and sustainable techniques for extracting bioactive compounds? How can their bioavailability and absorption in the human body be improved? What are the mechanisms through which these compounds exert their health effects? How can bioactive compounds be incorporated into functional foods and nutraceuticals? This Special Issue, on “Bioactive Compounds in Fruits and Vegetables: Processing, Bioavailability and Functional Properties”, seeks contributions of research and review articles that address these and related topics. We are particularly interested in studies that explore:

  • Novel and eco-friendly extraction techniques for bioactive compounds;
  • Methods to enhance the stability and bioavailability of these compounds;
  • Mechanistic insights into the health-promoting effects of specific bioactive components;
  • Applications of bioactive compounds in functional foods and supplements;
  • Analytical techniques for characterizing bioactive compounds and their efficacy.

We invite contributions that advance the understanding of bioactive compounds in fruits and vegetables and their impact on health and nutrition.

Your work will help bridge the gap between food science and human health, offering innovative solutions to pressing global challenges. We look forward to your valuable submissions. Please feel free to reach out with any questions or for further information.

Prof. Dr. Jian Li
Dr. Lingyu Zhang
Guest Editors

Prof. Dr. Yongbiao Zheng
Guest Editor Assistant

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Keywords

  • fruit
  • vegetable
  • anthocyanin
  • secondary metabolite
  • biosynthesis
  • food extraction
  • bioactive component

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Published Papers (3 papers)

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Research

18 pages, 570 KiB  
Article
Exploring the Bioavailability of Red Grape Skin Extract Polyphenols: A Caco-2 Cell Model Study
by Edurne Elejalde, Rosa María Alonso, María Carmen Villarán, Lucía Díez-Gutiérrez, María Chávarri and Iratxe López-de-Armentia
Foods 2025, 14(13), 2253; https://doi.org/10.3390/foods14132253 - 25 Jun 2025
Viewed by 301
Abstract
Grapes are a rich source of polyphenols with a positive impact on human health. Polyphenols need to be bioavailable to exert any beneficial effect. However, there is limited knowledge on the bioavailability of polyphenols in grape extracts. The intestinal permeability of nine polyphenols [...] Read more.
Grapes are a rich source of polyphenols with a positive impact on human health. Polyphenols need to be bioavailable to exert any beneficial effect. However, there is limited knowledge on the bioavailability of polyphenols in grape extracts. The intestinal permeability of nine polyphenols of a red grape skin extract (GSE) was investigated using the Caco-2 cell model that simulates the human intestinal epithelium: three anthocyanins (delphinidin-3-O-glucoside, petunidin-3-O-glucoside and malvidin-3-O-glucoside), three flavonols (quercetin-3-glucoside, kaempferol-3-galactoside and kaempferol-3-glucoside), two hydroxybenzoic acids (gallic acid and syringic acid) and one hydroxycinnamic acid (caftaric acid). Two concentrations of GSE (15 mg/mL and 22 mg/mL) were used. The transport efficiency (TE) through the Caco-2 monolayer was studied. Among anthocyanins, only malvidin-3-O-glucoside was detected at the basolateral side, which represents the bloodstream, with a TE of 1.08 ± 0.01%. Flavonols resulted in a variety of results depending on the GSE concentration. Among flavonols, kaempferol-3-glucoside showed the highest TE of 130 ± 3%. Gallic acid showed the highest TE among the investigated polyphenols with 188 ± 3%. This study provides data on the intestinal transport of red grape skin extract polyphenols that can be used to explore the underlying mechanisms of the intestinal absorption and the bioactivity of natural grape extracts. Full article
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26 pages, 1891 KiB  
Article
Developing Novel Plant-Based Probiotic Beverages: A Study on Viability and Physicochemical and Sensory Stability
by Concetta Condurso, Maria Merlino, Anthea Miller, Ambra Rita Di Rosa, Francesca Accetta, Michelangelo Leonardi, Nicola Cicero and Teresa Gervasi
Foods 2025, 14(12), 2148; https://doi.org/10.3390/foods14122148 - 19 Jun 2025
Viewed by 658
Abstract
Consumer demand for plant-based functional foods, especially probiotic beverages, has increased due to their health benefits and suitability as dairy-free alternatives. This study assessed, through a factorial combination, the stability of plant-based extracts (avocado, ginger, and tropical) individually inoculated with three commercial Lactobacillus [...] Read more.
Consumer demand for plant-based functional foods, especially probiotic beverages, has increased due to their health benefits and suitability as dairy-free alternatives. This study assessed, through a factorial combination, the stability of plant-based extracts (avocado, ginger, and tropical) individually inoculated with three commercial Lactobacillus strains (L. casei, L. plantarum, L. reuteri) and stored under refrigerated conditions during both primary (PSL) and secondary shelf life (SSL). Product shelf life was defined by probiotic viability, considering the functional threshold (≥6 log CFU/mL), which was maintained across all formulations throughout the storage period. Physicochemical parameters, including pH, titratable acidity, and colour, as well as volatile profile, remained stable, with only minor variations depending on the matrix and bacterial strain. Sensory evaluations (triangle and acceptability tests) confirmed that the probiotic juices were acceptable to consumers. Overall, the results demonstrate the feasibility of producing non-fermented, plant-based probiotic beverages that retain their functional properties and meet consumer sensory expectations, offering a promising alternative for vegan and lactose-intolerant individuals. Full article
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17 pages, 3587 KiB  
Article
Volvariella volvacea Polypeptide Mitigates Alcohol-Induced Liver Injury: A Multi-Omics Study
by Bingzhi Chen, Juanqin Chen, Huihua Wu, Fangyi Zhang, Lili Chen, Weibin Zhang, Jing Yang, Li Yuan, Yuji Jiang and Youjin Deng
Foods 2025, 14(9), 1557; https://doi.org/10.3390/foods14091557 - 29 Apr 2025
Viewed by 486
Abstract
This study investigated the hepatoprotective mechanisms of Volvariella volvacea fruiting body polypeptide (VVFP, 1–3 kDa) against acute alcohol-induced liver injury using multi-omics approaches. Male ICR mice pretreated with VVFP (100–400 mg/kg) showed significantly prolonged alcohol tolerance latency (p < 0.05) and accelerated [...] Read more.
This study investigated the hepatoprotective mechanisms of Volvariella volvacea fruiting body polypeptide (VVFP, 1–3 kDa) against acute alcohol-induced liver injury using multi-omics approaches. Male ICR mice pretreated with VVFP (100–400 mg/kg) showed significantly prolonged alcohol tolerance latency (p < 0.05) and accelerated sobriety recovery compared to controls. Integrated transcriptomics and metabolomics revealed VVFP’s dual regulatory effects: (1) transcriptional regulation of 36 endoplasmic reticulum stress genes (e.g., ERP57, Derl) through protein processing pathways (KEGG:04141), and (2) metabolic modulation of 23 hepatic metabolites, particularly phosphatidylcholines and organic acids, via amino acid biosynthesis and glycerophospholipid metabolism. Cross-omics analysis identified eight coregulated genes (Got1, Arg2, Srm, etc.) interacting with key metabolites (4-guanidinobutyric acid, GABA) through linoleic acid metabolism. These findings demonstrate VVFP’s therapeutic potential as a functional food ingredient by highlighting its ability to simultaneously target hepatic stress responses and metabolic homeostasis during alcohol detoxification. Full article
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