Functional Food and Safety Evaluation: Second Edition

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: 10 June 2026 | Viewed by 29875

Special Issue Editor


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Guest Editor
Faculty of Science and Technology, Technological and Higher Education Institute of Hong Kong, Rm 312, 20A Tsing Yi Road, Tsing Yi Island, N.T., Hong Kong, China
Interests: functional food; food safety; toxicology; nutraceutical; Chinese medicine; metabolomics
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Special Issue Information

Dear Colleagues,

Natural ingredients from foods have been found to be effective in terms of promoting health and preventing diseases, which is why different cultures commonly use natural ingredients to maintain physical well-being and reduce the risk of chronic diseases. The popularity of using functional foods to promote health is increasing, and the global functional food market has expanded in recent decades. Further in-depth research on the mechanistic pathways and safety evaluation of functional foods could encourage functional food producers to develop high-quality products for consumers.

Potential topics of interest in this Special Issue include but are not limited to:

(i) mechanistic studies on food functional ingredients;
(ii) clinical evaluation of functional foods
(iii) risk–benefit assessment of functional foods. The submission of original research articles, reviews, and short communications is encouraged.

Dr. Shun Wan Chan
Guest Editor

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Keywords

  • functional foods
  • food safety
  • nutraceutical
  • food ingredients
  • antioxidants
  • food toxicology

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Published Papers (4 papers)

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Research

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16 pages, 2473 KB  
Article
Phellinus linteus Mycelia Extracts Show Potent Antiviral and Immunomodulatory Effects in H1N1 Influenza Virus-Infected Mice
by I-Chen Li, Yi-Lin Chan, Wen-Ting Lu, Lynn-Huey Chiang, Tsung-Ju Li, Tsung-Lin Li, Chin-Chu Chen and Chang-Jer Wu
Foods 2025, 14(23), 4047; https://doi.org/10.3390/foods14234047 - 26 Nov 2025
Viewed by 1532
Abstract
Phellinus linteus, a medicinal mushroom with an ancient history in traditional medicine, serves as a valuable raw material for functional foods. While previous studies have shown promising antiviral effects, the present work is the most comprehensive investigation of P. linteus mycelial extracts [...] Read more.
Phellinus linteus, a medicinal mushroom with an ancient history in traditional medicine, serves as a valuable raw material for functional foods. While previous studies have shown promising antiviral effects, the present work is the most comprehensive investigation of P. linteus mycelial extracts and active compounds thereof against the H1N1 influenza virus infection in in vitro and animal models. Antiviral activity was evaluated using three treatment approaches (preventive, co-treatment, and therapeutic) in MDCK cells infected with H1N1 virus. In vivo studies employed male BALB/c mice exposed to aerosolized H1N1 virus (1.6 × 106 PFU/mL). In the animal experiment, mice received either P. linteus mycelia powder (PL) at 1000 mg/kg/day or PLw/PLe at 350 mg/kg/day for 7 days before and after infection. Ethanol extracts (PLe) demonstrated superior antiviral properties compared to water extracts (PLw) in cell survival and viral inhibition tests. Animal studies revealed that both PL and PLe significantly improved recovery after H1N1 infection, with survival rates of 60% and 40%, respectively, versus 25% in controls. The treatments effectively restored depleted immune cell populations, indicating broad immunomodulatory effects. These findings highlight the potential of P. linteus as a functional food ingredient with promising therapeutic applications against viral infections through its action on both innate and adaptive immune responses. Full article
(This article belongs to the Special Issue Functional Food and Safety Evaluation: Second Edition)
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21 pages, 2394 KB  
Article
Physicochemical and Sensory Properties of Davidson Plum (Davidsonia jerseyana) Sorbet, a Potential for New Functional Food Product
by Brittany Harriden, Costas Stathopoulos, Suwimol Chockchaisawasdee, Andrew J. McKune and Nenad Naumovski
Foods 2025, 14(16), 2902; https://doi.org/10.3390/foods14162902 - 21 Aug 2025
Cited by 4 | Viewed by 2211
Abstract
The Australian native foods, despite high phytochemical composition, are severely underutilized in research and on the commercial market. One of these plants is the Davidson plum (Davidsonia jerseyana), a nutrient-dense and sustainable food ingredient. The study aimed to develop functional fruit [...] Read more.
The Australian native foods, despite high phytochemical composition, are severely underutilized in research and on the commercial market. One of these plants is the Davidson plum (Davidsonia jerseyana), a nutrient-dense and sustainable food ingredient. The study aimed to develop functional fruit sorbets incorporating freeze-dried Davidson plum powder (0–20% w/w) and evaluate their physicochemical, antioxidant, and sensory properties. Sorbets were created using strawberry, raspberry, pomegranate, and Davidson plum bases and analyzed for nutritional content, color, melting rate, texture, and antioxidant capacity (Total Phenolic Content (TPC), Total Flavonoid Content (TFC), Ferric Reducing Antioxidant Power (FRAP), Cupric Reducing Antioxidant Capacity (CUPRAC), 2,2-Diphenyl-1-picrylhydrazyl (Radical Scavenging Assay (DPPH)), total proanthocyanin and anthocyanin content. Sensory evaluation was also conducted using a semi-trained panel. The results showed that increasing Davidson plum concentration led to higher antioxidant activity and slower melting rates. Sorbets containing 10% and 15% Davidson plum demonstrated the highest levels of phenolic and flavonoid compounds. However, sensory analysis indicated that sorbets with 5% and 10% Davidson plum, particularly those made with a strawberry base were the most acceptable in terms of flavour, texture, and overall appeal. These findings suggest that incorporating Davidson plum into frozen desserts, especially at lower concentrations, can enhance both the functional and sensory qualities of sorbets while offering potential health benefits. Full article
(This article belongs to the Special Issue Functional Food and Safety Evaluation: Second Edition)
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Review

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24 pages, 9295 KB  
Review
Cannabis Derivatives as Ingredients of Functional Foods to Combat the COVID-19 Pandemic
by Xiaoli Qin, Xiai Yang, Yanchun Deng, Litao Guo, Zhimin Li, Xiushi Yang and Chunsheng Hou
Foods 2025, 14(16), 2830; https://doi.org/10.3390/foods14162830 - 15 Aug 2025
Cited by 1 | Viewed by 3569
Abstract
Lower respiratory infections predominantly affect children under five and the elderly, with influenza viruses and respiratory syncytial viruses (including SARS-CoV-2) being the most common pathogens. The COVID-19 pandemic has posed significant global public health challenges. While vaccination remains crucial, its efficacy is limited, [...] Read more.
Lower respiratory infections predominantly affect children under five and the elderly, with influenza viruses and respiratory syncytial viruses (including SARS-CoV-2) being the most common pathogens. The COVID-19 pandemic has posed significant global public health challenges. While vaccination remains crucial, its efficacy is limited, highlighting the need for complementary approaches to mitigate immune hyperactivation in severe COVID-19 cases. Medicinal plants like Cannabis sativa show therapeutic potential, with over 85% of SARS-CoV-2-infected patients in China receiving traditional herbal treatments. This review explores the antiviral applications of cannabis and its bioactive compounds, particularly against SARS-CoV-2, while evaluating their pharmacological and food industry potential. Cannabis contains over 100 cannabinoids, terpenes, flavonoids, and fatty acids. Cannabinoids may block viral entry, modulate immune responses (e.g., suppressing pro-inflammatory cytokines via CB2/PPARγ activation), and alleviate COVID-19-related psychological stress. There are several challenges with pharmacological and food applications of cannabinoids, including clinical validation of cannabinoids for COVID-19 treatment and optimizing cannabinoid solubility/bioavailability for functional foods. However, rising demand for health-focused products presents market opportunities. Genetic engineering to enhance cannabinoid yields and integrated pharmacological studies are needed to unlock cannabis’s full potential in drug discovery and nutraceuticals. Cannabis-derived compounds hold promise for antiviral therapies and functional ingredients, though further research is essential to ensure safety and efficacy. Full article
(This article belongs to the Special Issue Functional Food and Safety Evaluation: Second Edition)
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35 pages, 852 KB  
Review
An Overview of the Current Scientific Evidence on the Biological Properties of Abelmoschus esculentus (L.) Moench (Okra)
by Carsten Tsun-Ka Kwok, Yam-Fung Ng, Hei-Tung Lydia Chan and Shun-Wan Chan
Foods 2025, 14(2), 177; https://doi.org/10.3390/foods14020177 - 8 Jan 2025
Cited by 11 | Viewed by 21332
Abstract
Abelmoschus esculentus (L.) Moench, commonly known as okra or lady’s finger, is an annual flowering plant belonging to the Malvaceae family. Okra is a native plant in Africa as well as a traditional medicine in Africa and India for treating different diseases and [...] Read more.
Abelmoschus esculentus (L.) Moench, commonly known as okra or lady’s finger, is an annual flowering plant belonging to the Malvaceae family. Okra is a native plant in Africa as well as a traditional medicine in Africa and India for treating different diseases and conditions. Today, okra is widely consumed as a vegetable and is increasingly recognized as a superfood due to its rich nutritional profile and potential pharmacological benefits. Research indicates that okra exhibits a range of biological activities, including antidiabetic, antihyperlipidemic, antifatigue, vasoprotective, hepatoprotective, antitumor, anti-inflammatory, and antimicrobial effects. Despite its promising therapeutic potential, research on the active compounds in okra and evaluating efficacy in clinical settings remains limited. This review aims to consolidate existing scientific knowledge on the biological and pharmacological properties of okra, thereby encouraging further investigation into its health benefits. Ultimately, this could pave the way for the development of functional foods or health supplements that leverage okra as a key ingredient to prevent chronic diseases and enhance overall health outcomes. Full article
(This article belongs to the Special Issue Functional Food and Safety Evaluation: Second Edition)
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