Epigenetics and Epigenomics of Insulin Resistance
A special issue of Epigenomes (ISSN 2075-4655).
Deadline for manuscript submissions: closed (10 December 2022) | Viewed by 444
Special Issue Editor
Special Issue Information
Dear Colleagues,
Insulin resistance is a pathophysiological condition that underlies type 2 diabetes (T2D) and obesity, two of the most challenging public health problems of our time. Approximately 11.3% of the United States population has diabetes, with the majority represented by T2D. In addition, obesity cases have reached epidemic proportions, with more than two-thirds of American adults being overweight or obese. Therefore, it is critical to research and identify the cellular, biochemical, and molecular abnormalities that contribute to the pathophysiology of T2D and obesity, including the underlying insulin resistance that exists in these complex metabolic disorders.
Insulin resistance is a reduced biological response of the skeletal muscle, adipose tissue, and liver to the biological effect of insulin. It results in decreased insulin-stimulated glucose uptake in skeletal muscle and white adipocytes and impaired suppression of liver glucose production. Many factors contribute to whole-body insulin resistance, including lifestyle variables such as a high-fat diet and physical inactivity, as well as genetic susceptibility. An emerging area of research is deciphering the epigenetic and epigenomic mechanisms that contribute to the insulin resistance that underlies T2D and obesity.
This Special Issue aims to provide a collection of original articles, reviews, meta-analyses, and case reports to advance the current knowledge on the epigenetics and epigenomics of insulin resistance. Relevant epigenetic mechanisms that can be included in this Special Issue are histone modifications, microRNAs, DNA methylation, and transcription factor regulation. This issue welcomes articles related to nuclear and mitochondrial genome epigenetics/epigenomics mechanisms. In addition, since insulin resistance is commonly found in obesity, type 2 diabetes, and related diseases such as cardiovascular disease, this Special Issue is inclusive of metabolic disorders related to insulin resistance.
Dr. Dawn K. Coletta
Guest Editor
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Keywords
- epigenetics
- methylation
- histone modifications
- microRNAs
- transcription factor
- insulin resistance
- obesity
- type 2 diabetes
- metabolic syndrome
- blood biomarkers
- tissues
- interventions
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