Announcements

This year, World Down Syndrome Day will be celebrated on 21 March 2025. Each year, approximately 3,000 to 5,000 children are born with this chromosome disorder. In 2025, we call for people around the world to “end the stereotypes”.

Aiming at improving the quality of life of people with Down syndrome and propelling the scientific development in this field, we would like to recommend some related articles, Special Issues, and journals in MDPI as suitable communication platforms for you. We believe that sharing research like this can help raise awareness of Down syndrome.

“When Language Is Not Enough: How to Explain ToM Abilities of Individuals with Williams Syndrome and Down Syndrome”
by Claire Touchet, Régis Pochon and Laure Ibernon
Disabilities 2025, 5(1), 4; https://doi.org/10.3390/disabilities5010004

“Assessing Uveitis Risk following Pediatric Down Syndrome Diagnosis: A TriNetX Database Study”
by Alan Y. Hsu, Yu-Hsun Wang, Chun-Ju Lin, You-Ling Li, Ning-Yi Hsia, Chun-Ting Lai, Hou-Ting Kuo, Huan-Sheng Chen, Yi-Yu Tsai and James Cheng-Chung Wei
Medicina 2024, 60(5), 710; https://doi.org/10.3390/medicina60050710

“Impact of Resistance Training on Body Composition and Physical Function in Individuals with Down Syndrome: A Meta-Analysis”
by Hou-Ting Kuo, Ting-Hsu Lee, Li-An Su, Li-Yun Wu, Ping-Yan Mao and Ciao-Ci Yang
Diagnostics 2024, 14(23), 2620; https://doi.org/10.3390/diagnostics14232620

“The Role of Tau Pathology in Alzheimer’s Disease and Down Syndrome”
by Ann-Charlotte Granholm and Eric D. Hamlett
J. Clin. Med. 2024, 13(5), 1338; https://doi.org/10.3390/jcm13051338

“Astrocytic Alterations and Dysfunction in Down Syndrome: Focus on Neurogenesis, Synaptogenesis, and Neural Circuits Formation”
by Beatrice Uguagliati and Mariagrazia Grilli
Cells 2024, 13(24), 2037; https://doi.org/10.3390/cells13242037

“Lipid Profile, Eating Habit, and Physical Activity in Children with Down Syndrome: A Prospective Study”
by Luca Pecoraro, Melissa Zadra, Francesco Cavallin, Silvana Lauriola, Giorgio Piacentini and Angelo Pietrobelli
Diseases 2024, 12(4), 68; https://doi.org/10.3390/diseases12040068

“Impact of Physical Activity on Autonomy and Quality of Life in Individuals with Down Syndrome: A Systematic Review”
by Antonio Muñoz-Llerena, Laura Ladrón-de-Guevara, Daniel Medina-Rebollo and Virginia Alcaraz-Rodríguez
Healthcare 2024, 12(2), 181; https://doi.org/10.3390/healthcare12020181

“Health Checks for People with Down Syndrome: A Pooled Analysis of Three Randomized Controlled Trials”
by Robert S. Ware, Catherine Franklin, Lyn McPherson and Nicholas G. Lennox
Disabilities 2024, 4(1), 101-110; https://doi.org/10.3390/disabilities4010007

“DNMT3B rs2424913 as a Risk Factor for Congenital Heart Defects in Down Syndrome”
by Dijana Majstorović, Anita Barišić, Ivana Babić Božović, Iva Bilić Čače, Neven Čače, Mauro Štifanić and Jadranka Vraneković
Genes 2023, 14(3), 576; https://doi.org/10.3390/genes14030576

“Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules”
by Lanzillotta, Chiara, and Fabio Di Domenico
Biomolecules 2021, 11(2), 266; https://doi.org/10.3390/biom11020266

“Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts”
by Panagaki, Theodora, Elisa B. Randi, and Csaba Szabo
Biomolecules 2020, 10(4), 653; https://doi.org/10.3390/biom10040653

“The Care Economy and Disability Inclusion”	“Fragile X Syndrome and Fragile X Premutation Associated Conditions”
“Physical Activity, Exercise, and Sport in People with Disabilities: Strategies for Health Promotion”	“Cellular and Molecular Alterations in the Down Syndrome Brain: A Starting Point for the Design of Therapeutic Approaches”