Nutrigenetics, Nutrigenomics, and Personalized Nutrition

Dear Colleagues,

The fields of nutrigenetics and nutrigenomics are driving a paradigm shift in nutrition science, providing mechanistic insights into how genetic variation influences nutrient metabolism and how dietary exposures, in turn, modulate gene expression and downstream physiological processes. Together, these disciplines underpin the emerging framework of personalized nutrition, which aims to tailor dietary strategies to individual biological profiles to promote health and prevent disease. The integration of multi-omics platforms, artificial intelligence, and increasingly diverse human populations has further expanded the scope and resolution of this work, accelerating its translational potential.

This Special Issue of Dietetics invites original research articles and reviews that examine the interface between genetic and epigenetic variation, nutritional exposures, and clinically relevant outcomes in human populations. The use of other omics approaches, such as the microbiome, will also be considered. Submissions grounded in mechanistic study designs are especially encouraged, particularly those in which the causal relationship between nutrient intake, genetic variation, and physiological response is articulated and well-supported. We welcome contributions from observational studies, clinical trials, intervention studies, and longitudinal cohorts, as well as investigations of gene–diet interactions, sex- and ancestry-specific responses, and omics-based biomarker discovery.

As computational tools such as AI enhance our ability to interpret complex nutritional and 'omics' datasets, there is a need for rigorous, data-rich, and clinically applicable research that can inform the development of equitable and biologically precise nutrition strategies. This Special Issue aims to bring together contributions from nutrition scientists, omics biologists, clinicians, dietitians, food and data scientists, and clinical epidemiologists working at the forefront of this multidisciplinary field.

Dr. Sara Mahdavi
Dr. Ahmed El-Sohemy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dietetics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• nutrigenetics
• nutrigenomics
• precision nutrition
• personalized nutrition
• gene–diet interactions
• multi-omics
• epigenetics
• proteomics
• metabolomics
• microbiome
• micronutrient metabolism
• functional foods and bioactive
• global nutrition and diversity