Special Issue "Biosensors-Based Diagnostics"

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Novel Diagnostic Technologies and Devices".

Deadline for manuscript submissions: 30 November 2019.

Special Issue Editor

Prof. Dr. Evangelyn C. Alocilja
E-Mail Website
Guest Editor
Nano-Biosensors Lab, Department of Biosystems and Agricultural Engineering Michigan State University, 524 S. Shaw Lane, Room 115, Farrall Agricultural Engineering Hall, East Lansing, MI 48824-1323, USA
Interests: nano-enabled biosensing, nanoparticles; nanowires, elecrochemical sensing approaches; infectious diseases; global health; food/water safety; biodefense; product integrity
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors are devices for detecting the presence, and oftentimes the concentration, of an analyte using an analyte-specific biological receptor that is intimately connected to a signal transducer and signal reader. Signal is generated when the analyte and receptor specifically interact, and the signal is finally reported by a reader. Since their inception, biosensors have played a major role in various forms of diagnosis, from infectious diseases to cancer to chronic ailments. The advantages of biosensors over classical or conventional methods include point-of-care utility, reduced size, rapid results, high sensitivity and specificity, affordability, accessibility, simplicity of operation, potential for multiplex analysis, and adaptability with other devices. This Special Issue on “Biosensors-Based Diagnostics” will cover all aspects of biosensor devices (biological receptors, signal transducers, and signal readers) and their diagnostic applications, such as for infectious diseases, pathogen detection, antimicrobial resistance, biomarker monitoring, and other related areas of concern.

Prof. Dr. Evangelyn Alocilja
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biological receptors
  • transducers
  • diseases
  • biomarkers

Published Papers (1 paper)

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Research

Open AccessArticle
Visual Detection of Dengue-1 RNA Using Gold Nanoparticle-Based Lateral Flow Biosensor
Diagnostics 2019, 9(3), 74; https://doi.org/10.3390/diagnostics9030074 - 11 Jul 2019
Abstract
Dengue is a rapidly spreading mosquito-borne viral disease. Early diagnosis is important for clinical screening, medical management, and disease surveillance. The objective of this study was to develop a colorimetric lateral flow biosensor (LFB) for the visual detection of dengue-1 RNA using dextrin-capped [...] Read more.
Dengue is a rapidly spreading mosquito-borne viral disease. Early diagnosis is important for clinical screening, medical management, and disease surveillance. The objective of this study was to develop a colorimetric lateral flow biosensor (LFB) for the visual detection of dengue-1 RNA using dextrin-capped gold nanoparticle (AuNP) as label. The detection was based on nucleic acid sandwich-type hybridization among AuNP-labeled DNA reporter probe, dengue-1 target RNA, and dengue-1 specific DNA capture probe immobilized on the nitrocellulose membrane. Positive test generated a red test line on the LFB strip, which enabled visual detection. The optimized biosensor has a cut-off value of 0.01 µM using synthetic dengue-1 target. Proof-of-concept application of the biosensor detected dengue-1 virus in pooled human sera with a cut-off value of 1.2 × 104 pfu/mL. The extracted viral RNA, when coupled with nucleic acid sequence-based amplification (NASBA), was detected on the LFB in 20 min. This study first demonstrates the applicability of dextrin-capped AuNP as label for lateral flow assay. The biosensor being developed provides a promising diagnostic platform for early detection of dengue infection in high-risk resource-limited areas. Full article
(This article belongs to the Special Issue Biosensors-Based Diagnostics)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Challenges for the Development and Implementation of Sensor Analytic Point Solutions (SNAPS) in Settings of Poverty
Authors: Diana Vanegas, et al.
Affiliation: Biosystems Engineering, Clemson University, 112 CELT, Anderson, SC 29625, USA
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