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Current Oncology
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The Evolving Role of Surgery in Multidisciplinary Care for Sarcoma...
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The Evolving Role of Surgery in Multidisciplinary Care for Sarcoma Patients

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Bone and Soft Tissue Oncology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1284

Special Issue Editors

Dr. Russell G. Witt

E-Mail Website
Guest Editor
Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
Interests: soft tissue sarcoma; immuno-oncology; skin malignancies; the effect of obesity on treatment response
Dr. Elizabeth Lilley

E-Mail Website
Guest Editor
Department of Surgery, Brigham and Women’s Hospital, Boston, MA 02130, USA
Interests: soft tissue sarcoma; malignant melanoma; palliative medicine
Dr. Heather Lyu

E-Mail Website
Guest Editor
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77005, USA
Interests: soft tissue sarcoma; clinical Informatics

Special Issue Information

Dear Colleagues,

Sarcomas represent a diverse group of malignancies originating from mesenchymal tissues, posing unique challenges in their management due to their varied histological subtypes and anatomical locations. As the cornerstone of definitive treatment, surgical intervention remains pivotal in achieving local control and potentially curative outcomes. Surgery also has a critical therapeutic role in control and palliation of incurable and advanced diseases. This Special Issue of Current Oncology explores the evolving role of surgery within the multidisciplinary care paradigm for patients with sarcoma. We welcome submissions that encompass advances in surgical techniques, integration with adjunctive therapies, and the critical interplay with medical and radiation oncology in management of patients with soft tissue sarcomas, highlighting the importance of a collaborative approach to optimize patient outcomes. Article types can include case reports, systematic reviews, and original research.

Dr. Russell G. Witt
Dr. Elizabeth Lilley
Dr. Heather Lyu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • soft tissue sarcoma
  • sarcoma
  • surgery
  • multidisciplinary approach
  • neoadjuvant therapy
  • adjuvant therapy
  • limb-sparing
  • histologic subtypes
  • oncologic outcomes

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Published Papers (3 papers)

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Research

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10 pages, 465 KB  
Article
Impact of Postoperative Infection on Lower Limb Function After Surgery for Malignant Bone and Soft Tissue Tumors: Data from a Nationwide Registry in Japan
by Takeshi Morii, Kenji Sato, Koichi Ogura, Tomohiro Shinozaki and Akira Kawai
Curr. Oncol. 2025, 32(8), 454; https://doi.org/10.3390/curroncol32080454 - 13 Aug 2025
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Abstract
Background: Due to the scarcity of cases, adjustments for confounding factors in analyses of the effects of postoperative infections on limb function after surgery for malignant bone and soft tissue tumors were insufficient in previous studies. One solution is to use big data [...] Read more.
Background: Due to the scarcity of cases, adjustments for confounding factors in analyses of the effects of postoperative infections on limb function after surgery for malignant bone and soft tissue tumors were insufficient in previous studies. One solution is to use big data from a nationwide registry. Methods: Data from the Bone and Soft Tissue Tumor Registry in Japan were used to examine the impact of postoperative infections on limb function after surgery for malignant bone and soft tissue tumors in the lower extremities. Limb function was evaluated using the Musculoskeletal Tumor Society (MSTS) score. Results: A total of 1099 soft tissue tumors and 410 bone tumor cases were included. Propensity score matching (PSM) was performed using significant factors in the propensity score logistic regression. After PSM, only “function” and “emotional acceptance” scores worsened in infection cases in the bone tumor group, while total MSTS scores remained unaffected in both the bone and soft tissue tumor groups. No subcategory scores worsened in the soft tissue tumor group. Conclusions: Our findings suggest that postoperative infections might not affect function in cases of soft tissue tumors and have only a limited impact in cases of bone tumors. Full article
(This article belongs to the Special Issue The Evolving Role of Surgery in Multidisciplinary Care for Sarcoma Patients)
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15 pages, 1144 KB  
Article
How Musculoskeletal Tumor Management Changed During the COVID-19 Pandemic: Data from a Nationwide Questionnaire Survey of Hospitals Specializing in Musculoskeletal Tumors in Japan
by Takeshi Morii, Shintaro Iwata, Kensaku Yamaga, Masanori Okamoto, Kosei Ando, Takaaki Tanaka and Jun Nishida
Curr. Oncol. 2025, 32(8), 453; https://doi.org/10.3390/curroncol32080453 - 12 Aug 2025
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Abstract
Background: While changes in clinical practice during the COVID-19 pandemic in Japan have been widely studied, data specific to bone and soft tissue tumor care remain limited. Methods: A nationwide web-based survey was conducted among hospitals specializing in musculoskeletal tumors. It assessed the [...] Read more.
Background: While changes in clinical practice during the COVID-19 pandemic in Japan have been widely studied, data specific to bone and soft tissue tumor care remain limited. Methods: A nationwide web-based survey was conducted among hospitals specializing in musculoskeletal tumors. It assessed the occurrence of COVID-19-related events (patient infections, outbreak clusters, and staff infections), delays in referral and diagnosis, postponement or cancellation of specific treatments, and changes in institutional management strategies. Results: Seventy-eight hospitals (91.7% of all specialized centers) responded. Patient infections, outbreak clusters, and staff infections were reported by 28.2%, 48.7%, and 53.8% of hospitals, respectively. While radiological exams and biopsies were largely maintained, patient referrals decreased significantly. Surgical treatment was more affected than chemotherapy or radiotherapy. Strategy changes included surgery delays or cancellations (48.7%) and prolonged follow-up intervals (20.5%). Among COVID-19-related factors, only direct patient infections were significantly associated with institutional changes in treatment policy. Conclusions: The pandemic substantially disrupted outpatient services and surgical care in musculoskeletal oncology. Patient infection was the main driver of treatment strategy modifications. Full article
(This article belongs to the Special Issue The Evolving Role of Surgery in Multidisciplinary Care for Sarcoma Patients)
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Review

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23 pages, 365 KB  
Review
Focused Ultrasound for Sarcomas: A Narrative Review
by Nidhi Kuchimanchi, Nicolle Sul, Sai Gajula, Margaret Mercante, Emily Tocco, Mackenzie M. Mayhew, Lynn T. Dengel, Ludimila Cavalcante, Lauren Hadley and Russell Gardner Witt
Curr. Oncol. 2025, 32(8), 452; https://doi.org/10.3390/curroncol32080452 - 12 Aug 2025
Viewed by 444
Abstract
Sarcomas are tumors of mesenchymal origin that are generally resistant to systemic therapies and prone to local recurrence despite current multimodal treatment approaches. Focused ultrasound (FUS) is a noninvasive therapeutic technology that may enhance standard treatment strategies for primary solid malignancies. FUS exerts [...] Read more.
Sarcomas are tumors of mesenchymal origin that are generally resistant to systemic therapies and prone to local recurrence despite current multimodal treatment approaches. Focused ultrasound (FUS) is a noninvasive therapeutic technology that may enhance standard treatment strategies for primary solid malignancies. FUS exerts its effects through diverse mechanisms, including high-intensity focused ultrasound (HIFU) thermal ablation, histotripsy, sonodynamic therapy, immunomodulation, and hyperthermia-enhanced drug delivery. In this narrative review, we summarize the mechanisms of focused ultrasound that have been investigated for the treatment of sarcomas and highlight the results of preclinical, veterinary, and clinical studies related to this area. Full article
(This article belongs to the Special Issue The Evolving Role of Surgery in Multidisciplinary Care for Sarcoma Patients)
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