Diagnosis, Monitoring, Prognostication and Treatment in Hepatocellular Carcinoma

A special issue of Current Oncology (ISSN 1718-7729).

Deadline for manuscript submissions: closed (29 March 2024) | Viewed by 2235

Special Issue Editor


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Guest Editor
Department of Medicine, Sunnybrook Odette Cancer Centre, Toronto, ON, Canada
Interests: medical oncology; hematology

Special Issue Information

Dear Colleagues,

Since the first tyrosine kinase inhibitor was approved for systemic treatment of advanced hepatocellular carcinoma (HCC) over a decade ago, there has been unprecedented progress in the management and understanding of HCC. Treatment options have been expanded to include immune checkpoint inhibitors, which have now become part of standard of care, and molecular profiling of HCC has identified important drivers that are leading to potentially actionable targets. In addition, newer interventional approaches have been successfully implemented in those with localized disease. Progress is still needed in identifying predictors of treatment response and to determine the role of earlier systemic treatment as adjunct therapy of localized disease. We invite researchers to address one of these topics in the management of HCC from early to late stage disease.

I look forward to receiving your contributions.

Dr. Yoo-Joung Ko
Guest Editor

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Published Papers (1 paper)

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10 pages, 3393 KiB  
Case Report
A Rare Early-Onset Fatal Complication after Transarterial Chemoembolization: A Case Report and Review of the Literature
by Monika Péčová, Jakub Benko, Martin Jozef Péč, Jakub Jurica, Simona Horná, Tomáš Bolek, Tatiana Hurtová, Ján Sýkora, Kamil Zeleňák, Matej Samoš and Juraj Sokol
Curr. Oncol. 2024, 31(4), 1961-1970; https://doi.org/10.3390/curroncol31040147 - 3 Apr 2024
Viewed by 1681
Abstract
Transarterial chemoembolization (TACE) is a minimally invasive treatment for liver cancer, often employed as a bridging therapy or destination treatment for non-operable cases. This case report discusses an 82-year-old woman with a large hepatocellular carcinoma (HCC) who underwent elective TACE due to the [...] Read more.
Transarterial chemoembolization (TACE) is a minimally invasive treatment for liver cancer, often employed as a bridging therapy or destination treatment for non-operable cases. This case report discusses an 82-year-old woman with a large hepatocellular carcinoma (HCC) who underwent elective TACE due to the high surgical risk associated with her tumor size. Unexpectedly, the patient experienced liver rupture 20 h post-procedure, leading to acute surgical intervention. Despite successful hemostasis during surgery, the patient succumbed to progressive multi-organ failure. We aimed to search the PubMed database for documented cases of ruptured HCC after TACE. This study highlights risk factors for spontaneous HCC rupture and specific factors associated with TACE-induced rupture. Transarterial embolization (TAE) is currently favored as the treatment method for spontaneous ruptures, while the optimal therapy for TACE-induced ruptures remains unclear. In conclusion, this case underscores the importance of recognizing the rare complication of HCC rupture post-TACE and the need for personalized risk assessment. While TAE emerges as a primary treatment choice, the lack of consensus necessitates further studies to establish evidence-based approaches for managing this uncommon yet life-threatening complication. Full article
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