Sarcoma Surgeries: Oncological Outcomes and Prognostic Factors

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Surgical Oncology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 507

Special Issue Editor


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Guest Editor
Division of Surgical Oncology, Department of Surgery, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC H3C 3J7, Canada
Interests: sarcoma; surgery

Special Issue Information

Dear Colleagues,

Soft tissue sarcomas (STSs) are rare malignant tumors of mesenchymal origin. The World Health Organization describes more than 80 different histological subtypes of sarcomas. STSs most commonly arise in the extremities, whereas retroperitoneal locations occur in 15% of cases. The mainstay treatment for STSs remains surgery. Completeness of resection has been shown to improve survival outcomes in numerous studies. Understanding the unique pathological and anatomical characteristics of sarcoma subtypes can guide surgical oncologists to perform appropriate surgeries.

Various factors have been shown to influence oncological outcomes: from achieving precise biopsies for accurate diagnosis to prompt referral to sarcoma experts are key elements to improve outcomes. Performing a complete resection and offering adjuvant treatments for selected patients are essential to optimize survival. This Special Issue of Current Oncology will focus on sarcoma surgery, from the preoperative steps to postoperative surveillance. It will address intraoperative challenges and discuss prognostic factors determining survival.

Dr. Mai-Kim Gervais
Guest Editor

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Keywords

  • sarcoma
  • surgery
  • resection
  • prognostic factors
  • survival

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Published Papers (1 paper)

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Research

13 pages, 891 KiB  
Article
The Role of [18F]FDG PET/CT Prior to and During Neoadjuvant Chemotherapy for Soft Tissue Sarcomas
by Stijn J.C. van der Burg, Bernies van der Hiel, Lotte Heimans, J. Martijn Kerst, Michel W.J.M. Wouters, Petur Snaebjornsson, Yvonne M. Schrage, Winette T.A. van der Graaf and Winan J. van Houdt
Curr. Oncol. 2025, 32(5), 257; https://doi.org/10.3390/curroncol32050257 - 28 Apr 2025
Viewed by 217
Abstract
This retrospective, single-center study investigates the association between PET parameters and pathological response or disease recurrence in patients with soft tissue sarcoma (STS) treated with neoadjuvant chemotherapy (NACT). The maximum standardized uptake value (SUVmaxBL), metabolic tumor volume (MTVBL), and [...] Read more.
This retrospective, single-center study investigates the association between PET parameters and pathological response or disease recurrence in patients with soft tissue sarcoma (STS) treated with neoadjuvant chemotherapy (NACT). The maximum standardized uptake value (SUVmaxBL), metabolic tumor volume (MTVBL), and total lesion glycolysis (TLGBL) were measured at baseline [18F]FDG PET/CT and the change in percentage (ΔSUVmax, ΔMTV, ΔTLG) from baseline to early evaluation [18F]FDG PET/CT was calculated. The optimal cutoff values of the different PET parameters for pathological response, defined as <10% residual viable tumor (RVT) or >15% fibrosis/hyalinization, and recurrence-free survival were obtained for analysis. Forty-two patients who underwent baseline [18F]FDG PET/CT and NACT followed by surgery were included between January 2015 and January 2023. The primary diagnoses were angiosarcoma (n = 15), leiomyosarcoma (n = 15), sarcoma not otherwise specified (n = 9) and synovial sarcoma (n = 3). Twenty-eight (66.6%) patients underwent an early evaluation PET/CT. MTVBL, TLGBL, and ΔSUVmax (p = 0.024; p = 0.042, p = 0.009, respectively) values above the cutoff were associated with a pathological response based on RVT. ΔSUVmax, ΔMTV, and ΔTLG (p = 0.002; p = 0.019; p = 0.039, respectively) values above the cutoff were positively related to >15% fibrosis/hyalinization. MTVBL, TLGBL, and ΔMTV (p = 0.014; p = 0.022; p = 0.034, respectively) values above the cutoff were prognostic for the recurrence of disease. [18F]FDG PET/CT has a promising role in STS patients treated with NACT. Full article
(This article belongs to the Special Issue Sarcoma Surgeries: Oncological Outcomes and Prognostic Factors)
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