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Cosmetics
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New Perspectives in Cosmetics and Dermatology: Mechanisms and Therapies—2nd Edition
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New Perspectives in Cosmetics and Dermatology: Mechanisms and Therapies—2nd Edition

A special issue of Cosmetics (ISSN 2079-9284). This special issue belongs to the section "Cosmetic Dermatology".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1874

Editor

Dr. Montserrat Fernández-Guarino

E-Mail Website
Guest Editor
Dermatology Department, Hospital Universitario Ramony Cajal, 28034 Madrid, Spain
Interests: dermatology; skin cancer; phototherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cosmetics have significantly evolved in recent years, expanding beyond aesthetics into fields of scientific and dermatological relevance. In this Special Issue, we will explore the role of cosmetics from various perspectives: as a science that studies the biological mechanisms of the skin, as a complementary tool in clinical dermatology, and as an adjuvant therapy for treating various skin conditions.

Additionally, we will address the growing influence of cosmetics in a “new era”, where advances in molecular research, personalised treatments, and integration with dermatological therapies offer new possibilities to enhance skin health and well-being. We invite scientists, dermatologists, and researchers to submit their experiences, clinical studies, and reviews from this constantly evolving field to this Special Issue.

We aim to develop a Special Issue that will become a reference in this fascinating intersection between cosmetics and dermatological science.

Dr. Montserrat Fernández-Guarino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cosmetics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cosmetics
  • immunoderamtology
  • cutaneous lymphoma
  • cutaneous drug reaction
  • erythroderma
  • psoriasis
  • atopic dermatitis
  • eczematous reactions

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

19 pages, 1800 KB  
Article
Beyond Nano-Delivery: Synerjet-Assisted Transdermal Delivery of Nano-Formulated Nicotinamide Mononucleotide (Nano-NMN) for Comprehensive Skin Rejuvenation
by Wonkyu Hong, Jaewoo Kim, Seongmin Noh, Joonho Shim, Seok-Kwang Park and Mihwa Kim
Cosmetics 2026, 13(4), 172; https://doi.org/10.3390/cosmetics13040172 (registering DOI) - 3 Jul 2026
Viewed by 153
Abstract
This study aimed to evaluate whether the Synerjet system can maximize the transdermal delivery and skin rejuvenation of nano-NMN. In a 4-week split-face trial (n = 21), this combination demonstrated marked clinical superiority over topical nano-NMN alone (p < 0.001), yielding enhanced [...] Read more.
This study aimed to evaluate whether the Synerjet system can maximize the transdermal delivery and skin rejuvenation of nano-NMN. In a 4-week split-face trial (n = 21), this combination demonstrated marked clinical superiority over topical nano-NMN alone (p < 0.001), yielding enhanced improvements in wrinkles (with 170.56% relative improvement in periorbital and 154.45% in nasolabial region compared to the control group), pore volume (176.62%), and deep hydration (188.02%). Regarding dermal integrity, the test group showed a 111.56% superior increment in skin elasticity and a 149.75% more effective optimization of melanin intensity relative to the control. Notably, deep-tissue hydration at a 2.5 mm depth demonstrated a 188.02% higher gain, suggesting that the modality significantly fortifies the skin’s physiological moisture reservoir. The test group exhibited a marked improvement over the control across all cutaneous parameters (p < 0.001). Our findings demonstrate that a new combinatorial approach using EP-assisted microjet of a Synerjet system after cold plasma pretreatment and a nano-NMN 10% ampoule resulted in significantly greater improvements in wrinkles, pores, elasticity, pigmentation, and deep skin hydration compared to topical application alone. Consequently, these results demonstrated that the Synerjet system effectively overcame the inherent limitations of nano-delivery technologies, offering a promising modality for advanced cutaneous rejuvenation and a robust framework for future professional dermatological treatments. Full article
(This article belongs to the Special Issue New Perspectives in Cosmetics and Dermatology: Mechanisms and Therapies—2nd Edition)
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13 pages, 3333 KB  
Article
A Double-Blind Randomized Preliminary Study Comparing the Efficacy and Tolerance of a New Retinoid Combination with the Equivalent Retinol Concentration in the Treatment of Skin Aging
by Maria Teresa Truchuelo-Díez, Ana López-Sánchez, Luisa Haya, Juan José Andrés-Lencina and María Vitale
Cosmetics 2026, 13(3), 133; https://doi.org/10.3390/cosmetics13030133 - 26 May 2026
Viewed by 735
Abstract
Background: Retinol has consistently demonstrated efficacy in improving signs of skin aging. However, recent European Union regulations have limited its cosmetic concentration to 0.3%, creating the need for new formulations to be capable of maintaining high efficacy, safety, and tolerance. Material and Methods: [...] Read more.
Background: Retinol has consistently demonstrated efficacy in improving signs of skin aging. However, recent European Union regulations have limited its cosmetic concentration to 0.3%, creating the need for new formulations to be capable of maintaining high efficacy, safety, and tolerance. Material and Methods: This clinical study aimed to evaluate and compare the rejuvenating effects and tolerance of a 0.5% retinol serum with a new equivalent technology, Retinduo®, which previously showed promising preclinical results. A single-center, prospective, randomized, controlled, double-blind, two-arm parallel study was conducted in 40 Caucasian women aged 38–60 years with moderate photoaging (Glogau II). A total of 20 participants applied Retinduo® serum and 20 applied retinol 0.5%, following a progressive application protocol. Clinical and instrumental assessments measured hydration, firmness, elasticity, tone homogeneity, melanin levels, skin roughness, wrinkle parameters, and stratum corneum thickness. Results and Discussion: Both formulations significantly improved hydration, firmness, and elasticity from day 28 onward. Retinduo® showed a significant increase in viscoelasticity (R8) from day 56, while retinol 0.5% did not demonstrate significant changes in this parameter. Melanin reduction was observed with Retinduo® at days 28 and 56 and with retinol 0.5% just at day 28. Although a reduction in melanin was observed with both ingredients, the reduction was more significant with Retinduo® at 56 days. Both treatments reduced the thickness of the stratum corneum; however, with Retinduo®, a significant and more pronounced reduction was achieved after 3 months of treatment (30% (p = 0.0001) vs. 12% (p = 0.033). Retinduo® demonstrated significant wrinkle depth reduction at day 28 and in wrinkle amplitude (width and length of wrinkles) at the end of treatment, while 0.5% retinol showed a positive trend in this parameter. Both products exhibited excellent tolerance. Conclusions: Overall, Retinduo® achieved comparable or slightly superior anti-aging effects while aligning with current European regulatory limits. Full article
(This article belongs to the Special Issue New Perspectives in Cosmetics and Dermatology: Mechanisms and Therapies—2nd Edition)
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