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Molecular Insights into Melanogenesis and Melanoma Development
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Molecular Insights into Melanogenesis and Melanoma Development

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 1404

Special Issue Editor

Dr. Urszula Kazimierczak

E-Mail Website
Guest Editor
Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Rokietnicka Street 8, 61-806 Poznan, Poland
Interests: melanoma; LATS1; melanogenesis; oxidative stress; epigenetic; cancer; RNA

Special Issue Information

Dear Colleagues,

The main function of melanin is protection from photodamage induced by UV irradiation. However, it also regulates the processes that affect the behavior of melanoma. Melanoma is the most aggressive skin cancer, with a growing number of incidents worldwide and no effective cure in the metastatic stage so far. The pathway responsible for melanin synthesis differs in normal and malignant melanocytes. Melanocyte transformation occurs when DNA repair or cell-cycle control mechanisms are damaged. In most cases, melanocyte transformation results in a benign melanocytic neoplasm (such as a naevus) forming. In malignant melanocytes, the process of melanogenesis is frequently upregulated, suggesting possible therapeutic targets. The etiology of melanoma or naevi is complex and heterogeneous, constituting an interplay between the environment, a person's phenotype, and genetic risk, along with acquired molecular alterations.

There are several pathways and processes engaged in melanoma pathogenesis that have been extensively explored in recent years. However, the mechanism and precise impact of melanin on melanoma progression is still not clear.

In this Issue, we aim to highlight the use of current technologies for the discovery of new melanoma susceptibility genes, new molecular targets for therapy, and novel pathways to understand melanogenesis and melanoma development. Original research articles and review papers are very welcome.

Dr. Urszula Kazimierczak
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • melanoma
  • genetics
  • genomics
  • biomarkers
  • melanoma pathology
  • RNA
  • biomarkers and molecular inhibitors

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Published Papers (1 paper)

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Research

21 pages, 5101 KiB  
Article
Insights on the Anti-Inflammatory and Anti-Melanogenic Effects of 2′-Hydroxy-2,6′-dimethoxychalcone in RAW 264.7 and B16F10 Cells
by Sung-Min Bae and Chang-Gu Hyun
Curr. Issues Mol. Biol. 2025, 47(2), 85; https://doi.org/10.3390/cimb47020085 - 29 Jan 2025
Viewed by 1035
Abstract
Chalcones are recognized for their diverse pharmacological properties, including anti-inflammatory and anti-melanogenic effects. However, studies on 2′-hydroxy-2-methoxychalcone derivatives remain limited. This study investigated the anti-inflammatory and melanin synthesis-inhibitory effects of three derivatives: 2′-hydroxy-2,4-dimethoxychalcone (2,4-DMC), 2′-hydroxy-2,5′-dimethoxychalcone (2,5′-DMC), and 2′-hydroxy-2,6′-dimethoxychalcone (2,6′-DMC). In lipopolysaccharide (LPS)-stimulated RAW [...] Read more.
Chalcones are recognized for their diverse pharmacological properties, including anti-inflammatory and anti-melanogenic effects. However, studies on 2′-hydroxy-2-methoxychalcone derivatives remain limited. This study investigated the anti-inflammatory and melanin synthesis-inhibitory effects of three derivatives: 2′-hydroxy-2,4-dimethoxychalcone (2,4-DMC), 2′-hydroxy-2,5′-dimethoxychalcone (2,5′-DMC), and 2′-hydroxy-2,6′-dimethoxychalcone (2,6′-DMC). In lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, 2,6′-DMC demonstrated a superior inhibition of nitric oxide (NO) production, pro-inflammatory cytokines, and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) compared to the other derivatives. A mechanistic analysis revealed that 2,6′-DMC modulates the NF-κB and MAPK signaling pathways to attenuate inflammation. Additionally, 2,6′-DMC exhibited a significant inhibition of α-melanocyte-stimulating hormone (α-MSH)-induced melanin synthesis in B16F10 melanoma cells by downregulating tyrosinase, TRP-1, TRP-2, and MITF expression. This regulation was achieved through the suppression of the Wnt/β-catenin, PI3K/AKT, MAPK, and PKA/CREB pathways. Compared to 2,4-DMC and 2,5′-DMC, 2,6′-DMC’s structural configuration, characterized by methoxy groups at the 2- and 6′-positions, contributed to its enhanced molecular stability and binding affinity, amplifying its inhibitory effects. A primary skin irritation test confirmed that 2,6′-DMC exhibited minimal irritation, demonstrating its safety for dermal applications. These findings suggest that 2,6′-DMC holds promise as a dual-function agent for managing inflammatory conditions and hyperpigmentation-related disorders. Full article
(This article belongs to the Special Issue Molecular Insights into Melanogenesis and Melanoma Development)
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