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Oral Cancer: Prophylaxis, Etiopathogenesis and Treatment, 2nd Edition

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 890

Special Issue Editors


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Guest Editor
Department of Integrated Mountain Territorial Development, “Costin C. Kiriţescu” National Institute of Economic Research—Center for Mountain Economics (INCE-CEMONT) of Romanian Academy, 725700 Vatra Dornei, Romania
Interests: plant/lichen secondary metabolites-identification and pharmacological potential; phenolic compounds; antibiotics; antimicrobial activity; in vitro anticancer activity; oral cancer; ROS; oxidative stress; antioxidants/pro-oxidants; healthcare; health environment; foods; diet analysis; nutrition; nutritional supplements; case studies
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956 Bucharest, Romania
Interests: pharmaceutical technology; cyclodextrin inclusion complexes; drug delivery systems; biopharmaceuticals; pharmaceutical processes; drug release profiles; drug design; development, optimization and manufacturing of pharmaceutical products; pre- and post-compression parameters for solid dosage forms; preformulation studies on pharmaceuticals; physico-chemical characterization of materials; quality of pharmaceutical forms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral cancer continues to be a leading cause of death worldwide; it is prevalent in developing countries, where regularly smoking, chewing tobacco and betel nuts and consuming alcohol are very common habits. Oral inflammation may also play a role in the pathophysiology of oral cancers due to the involvement of several inflammatory pathways. Moreover, oral squamous cell carcinoma is associated with several oral bacteria and virus carriage. It has been reported that oral cancer patients have significantly higher levels of Candida albicans genotype A strain than noncancer patients. This strain has also been linked to leukoplakic lesions. Immunosuppression has also been linked to the development of oral cancer in patients undergoing bone marrow and renal transplantation. Despite the availability of novel therapeutic options, the 5-year survival rate for oral cancer in most countries remains below 50%. Therefore, effective therapies to prevent the development of oral cancer are required, and potential natural products and phytochemicals are being investigated for use in the treatment of oral diseases. These natural compounds may be supplemented in their natural form or incorporated into bars, powders, liquids, gels, tablets or capsules, toothpaste, mouthwashes, lozenges, oral gels or other pharmaceutical products.

This Special Issue will focus on recent research on etiopathogenesis, biomarkers, natural products with anticancer activity through various mechanisms, and novel pharmaceutical formulations with potential applications in oral cancer prophylaxis and treatment.

You can read the publications in the first volumes of this Special Issue here:

https://www.mdpi.com/journal/cimb/special_issues/U2TX90NIK1

Dr. Violeta Popovici
Dr. Emma Adriana Ozon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral carcinogenesis
  • biomarkers
  • cell signaling
  • natural products
  • phytochemicals
  • medicinal plants
  • essential oils
  • antimicrobial activity
  • cytotoxicity
  • phytotherapy
  • drug discovery
  • drug delivery
  • pharmaceutical formulation

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Published Papers (1 paper)

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Review

22 pages, 647 KiB  
Review
Ameloblastic Carcinoma: A 40-Year Scoping Review of the Literature
by Maria Giulia Cristofaro, Ida Barca, Angelo R. Sottile and Francesco Ferragina
Curr. Issues Mol. Biol. 2025, 47(4), 261; https://doi.org/10.3390/cimb47040261 - 8 Apr 2025
Viewed by 652
Abstract
Background: Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor with limited knowledge surrounding its pathogenesis, molecular pathways, clinical behavior, treatment, and prognosis. This 40-year literature scoping review aims to enhance the comprehension of this complex condition, looking closely at how AC works [...] Read more.
Background: Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor with limited knowledge surrounding its pathogenesis, molecular pathways, clinical behavior, treatment, and prognosis. This 40-year literature scoping review aims to enhance the comprehension of this complex condition, looking closely at how AC works at molecular and pathophysiological levels and what causes it to develop. Methods: The PUBMED, Medline, Scopus, and Cochrane central databases were searched, including articles from 1984 to date. Articles reporting epidemiological, clinical, instrumental, and histopathological data were included. Results: Out of the 375 articles examined, 52 met the inclusion criteria, yielding a total of 80 cases of AC. All cases before 1984 were excluded from the analysis, as were all that did not provide information on patient survival. Several molecular mechanisms associated with its development and progression were identified; these help in early diagnosis. Moreover, AC can spread locally, making a radical surgical approach necessary. There is still no agreement on how to manage neck dissection. Surgical removal followed by monitoring is an important part of managing AC. Conclusions: Advancements in biological and molecular insights have the potential to facilitate earlier diagnosis and treatment. These could lead to improvements in patients’ quality of life and long-term survival. Full article
(This article belongs to the Special Issue Oral Cancer: Prophylaxis, Etiopathogenesis and Treatment, 2nd Edition)
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