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Molecular Mechanism of pH Regulation: From Physiology to Pathology

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 818

Special Issue Editor

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Guest Editor
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Interests: pH regulation; acid/base disturbance; metabolic acidosis; sodium-bicarbonate transporter; brain acidosis; acidosis in cancer; structure-function of acid/base transporter
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Special Issue Information

Dear Colleagues,

pH is an important biological factor that regulates cell function. Hydrogen ions interact with proteins and change their structure and function, resulting in modified cellular processes. Maintaining a normal pH is frequently challenged under both physiological and pathological conditions. For example, pH decreases when metabolic activity increases during heavy exercise or when blood supply is inefficient in ischemia. Typically, acidification inhibits cellular activity, such that severe acidification is deleterious to normal cells and causes cell death. On the other hand, acidification can be adversely beneficial under some pathological conditions. Cancer cells thrive in acidic microenvironments and undergo adaptations to promote survival and proliferation. The effects of pH abnormalities on physiology and relevant diseases have been studied over the past decades. This Special Issue focuses on the current understanding of pH regulation in various model systems and/or its involvement in diseases. The topic is open to original studies, reviews, and new methodologies, ranging from the molecular and cellular level to integrated organ systems.

You may choose our Joint Special Issue in IJMS.

Dr. Inyeong Choi
Guest Editor

Manuscript Submission Information

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  • pH regulation
  • acid base transporter
  • acid base disturbance
  • acidosis
  • intracellular pH
  • NBC
  • NHE
  • cancer

Published Papers (1 paper)

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12 pages, 4845 KiB  
Identification of Aly1 and Aly2 as Modulators of Cytoplasmic pH in Saccharomyces cerevisiae
by Guoyong Liu, Xiuli Han, Xiang Yu, Yu Wang, Jinbiao Ma and Yongqing Yang
Curr. Issues Mol. Biol. 2024, 46(1), 171-182; - 25 Dec 2023
Viewed by 620
The regulation of intracellular pH in yeast (Saccharomyces cerevisiae) cells is critical for cell function and viability. In yeast, protons (H+) can be excreted from the cell by plasma membrane ATPase PMA1 and pumped into vacuoles by vacuolar H [...] Read more.
The regulation of intracellular pH in yeast (Saccharomyces cerevisiae) cells is critical for cell function and viability. In yeast, protons (H+) can be excreted from the cell by plasma membrane ATPase PMA1 and pumped into vacuoles by vacuolar H+-ATPase. Because PMA1 is critical to the survival of yeast cells, it is unknown whether other compensatory components are involved in pH homeostasis in the absence of PMA1. To elucidate how intracellular pH is regulated independently of PMA1, we employed a screening approach by exposing the yeast haploid deletion mutant library (ver 4.0) to the selective plant plasma membrane H+-ATPase inhibitor PS-1, which we previously reported. After repeated screenings and verification, we identified two proteins, Aly1 and Aly2, that play a role in the regulation of intracellular pH when PMA1 is deficient. Our research uncovers a new perspective on the regulation of intracellular pH related to PMA1 and also preliminarily reveals a role for Aly1 and Aly2 in the regulation of intracellular pH. Full article
(This article belongs to the Special Issue Molecular Mechanism of pH Regulation: From Physiology to Pathology)
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