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Molecular Mechanisms of Ion Transport across Cell Membranes

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2067

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Guest Editor
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Interests: sodium bicarbonate transporter; molecular mechanism; structure-function; ion selectivity; alcoholism; addiction
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Special Issue Information

Dear Colleagues,

Ion transporters play vital roles in a variety of cell functions, such as ion gradients across cell membranes, regulation of chemical signals, pH homeostasis, and solute absorption and secretion. The function, localization, and regulation of various ion transporters have been studied in detail, and their roles in tissue or organ physiology have also been examined. The current information on the cellular and functional properties of transporters is well documented, although some variability exists depending upon types of ion transporters. Moreover, structure function analysis, mutagenesis studies, and molecular modeling have identified specific residues and domains that contribute to molecular functional properties, such as ion binding sites, selectivity, and translocation. Crystallography and molecular dynamics simulations have provided new insights into the detailed structure of many transporters. This Special Issue focuses on the current progress in the molecular mechanism of ion transport across cell membranes. The topics include how ions are bound to the binding sites, selected, and translocated via transporters. These topics will be particularly appealing to those interested in specific attention toward clinical and therapeutic aspects of ion transporters. The topic is open to articles and reviews, ranging from molecular levels to cellular and integrated levels. 

Dr. Inyeong Choi
Guest Editor

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  • ion transporter
  • molecular mechanism
  • binding
  • selectivity
  • translocation

Published Papers (1 paper)

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16 pages, 3562 KiB  
Molecular Physiological Evidence for the Role of Na+-Cl Co-Transporter in Branchial Na+ Uptake in Freshwater Teleosts
by Shang-Wu Shih, Jia-Jiun Yan, Shao-Wei Lu, Ya-Ting Chuang, How-Wei Lin, Ming-Yi Chou and Pung-Pung Hwang
Int. J. Mol. Sci. 2023, 24(7), 6597; https://doi.org/10.3390/ijms24076597 - 1 Apr 2023
Viewed by 1475
The gills are the major organ for Na+ uptake in teleosts. It was proposed that freshwater (FW) teleosts adopt Na+/H+ exchanger 3 (Nhe3) as the primary transporter for Na+ uptake and Na+-Cl co-transporter (Ncc) as [...] Read more.
The gills are the major organ for Na+ uptake in teleosts. It was proposed that freshwater (FW) teleosts adopt Na+/H+ exchanger 3 (Nhe3) as the primary transporter for Na+ uptake and Na+-Cl co-transporter (Ncc) as the backup transporter. However, convincing molecular physiological evidence to support the role of Ncc in branchial Na+ uptake is still lacking due to the limitations of functional assays in the gills. Thus, this study aimed to reveal the role of branchial Ncc in Na+ uptake with an in vivo detection platform (scanning ion-selective electrode technique, SIET) that has been recently established in fish gills. First, we identified that Ncc2-expressing cells in zebrafish gills are a specific subtype of ionocyte (NCC ionocytes) by using single-cell transcriptome analysis and immunofluorescence. After a long-term low-Na+ FW exposure, zebrafish increased branchial Ncc2 expression and the number of NCC ionocytes and enhanced gill Na+ uptake capacity. Pharmacological treatments further suggested that Na+ is indeed taken up by Ncc, in addition to Nhe, in the gills. These findings reveal the uptake roles of both branchial Ncc and Nhe under FW and shed light on osmoregulatory physiology in adult fish. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Ion Transport across Cell Membranes)
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