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The Role of Bioactives in Inflammation, 2nd Edition

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 372

Special Issue Editor

Special Issue Information

Dear Colleagues,

An inflammatory response is a complex physiological defense mechanism of the body against harmful stimuli. However, a prolonged, excessive inflammatory response may damage the body in the long term and lead to chronic diseases. Recent studies suggest that natural bioactives play a crucial role in inflammation and disease, helping reduce the risks associated with inflammatory diseases, improving the state of wellbeing, and even improving the quality of life. Furthermore, different research models and methodologies can demonstrate the effectiveness and explain the biological mechanisms of such bioactives for inflammatory diseases. In this Special Issue, we welcome articles highlighting the current status of anti-inflammatory compounds, natural products, synthesized compounds, novel mechanisms, and targets of anti-inflammation.

Dr. Chan-Yen Kuo
Guest Editor

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Keywords

  • anti-inflammation
  • bioactives
  • drug research and development
  • inflammatory diseases
  • natural products
  • signaling
  • synthesized compounds

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Published Papers (1 paper)

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Research

18 pages, 4537 KiB  
Article
Colostrum-Derived Exosomal Lactoferrin Promotes Skin Fibroblast Regeneration by Suppressing Inflammatory Responses
by Chu-Hsun Cheng, Wei-Jer Hong, Chien-Nien Li, Yung-Hsueh Huang, Jeng-Haw Tsai, Chih-Yuan Huang, Jen-Chin Wu, Chan-Yen Kuo and Wen-Chun Kuo
Curr. Issues Mol. Biol. 2025, 47(7), 549; https://doi.org/10.3390/cimb47070549 - 15 Jul 2025
Viewed by 286
Abstract
Lactoferrin (LF), a multifunctional glycoprotein found abundantly in bovine colostrum, is known for its regenerative and anti-inflammatory properties. In this study, we investigated the wound healing and immunomodulatory effects of colostrum-derived exosome-encapsulated lactoferrin (EV-exoLF) on dermal fibroblasts. EV-exoLF was isolated and characterized via [...] Read more.
Lactoferrin (LF), a multifunctional glycoprotein found abundantly in bovine colostrum, is known for its regenerative and anti-inflammatory properties. In this study, we investigated the wound healing and immunomodulatory effects of colostrum-derived exosome-encapsulated lactoferrin (EV-exoLF) on dermal fibroblasts. EV-exoLF was isolated and characterized via nanoparticle tracking analysis and flow cytometry. Functional assays demonstrated that EV-exoLF significantly promoted fibroblast viability and migration in both mouse NIH/3T3 and human HS-68 cell lines. Furthermore, EV-exoLF reduced the expression of pro-inflammatory cytokines (IL-1 and IL-6) and phosphorylated JNK in lipopolysaccharide (LPS)-treated fibroblasts. These findings suggest that EV-exoLF not only enhances fibroblast-mediated wound closure but also mitigates inflammation, highlighting its therapeutic potential in skin regeneration. Colostrum-derived exosomal lactoferrin may serve as a promising natural, cell-free strategy for managing inflammatory skin conditions and improving wound healing outcomes. Full article
(This article belongs to the Special Issue The Role of Bioactives in Inflammation, 2nd Edition)
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