Special Issue "Advances in Pediatric Heart Disease Research—Neonatal Interventions"

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Global and Public Health".

Deadline for manuscript submissions: closed (31 August 2021).

Special Issue Editors

Dr. Shyam K. Sathanandam
E-Mail Website
Guest Editor
Division of Pediatric Cardiology, Department of Pediatrics, LeBonheur Children’s Hospital, University of Tennessee, Memphis, TN 38104, USA
Interests: novel stent technologies; protocols for radiation reduction; 3D rotational angiography and 3D multimodality fusion; cardiovascular manifestations of histoplasmosis; pediatric catheter-based device development
Prof. Dr. Jeffrey A. Towbin
E-Mail Website
Guest Editor
Division of Pediatric Cardiology, Department of Pediatrics, LeBonheur Children’s Hospital, University of Tennessee, Memphis, TN 38104, USA
Interests: diagnostic and therapeutic advances for cardiomyopathies; heart failure and heart transplantation; cardiovascular genetics; cardio-oncology
Special Issues and Collections in MDPI journals
Prof. Dr. Ranjit Philip
E-Mail Website
Guest Editor
Division of Pediatric Cardiology, Department of Pediatrics, LeBonheur Children’s Hospital, University of Tennessee, Memphis, TN 38104, USA
Interests: congenital heart disease; patent ductus arteriosus; hypoplastic left heart syndrome; exercise physiology; pediatric echocardiography; interventional echocardiography; hypertension; pulmonary hypertension

Special Issue Information

Dear Colleagues,

Procedures in the neonatal period are associated with increased risks. With the progress in neonatal intensive care techniques, survival in extremely low birth-weight preterm infants continues to improve. Recent advances in resuscitative, diagnostic, and therapeutic choices for congenital and acquired heart disease in this cohort have considerably developed. We invite original research (both clinical and translational) and review articles highlighting these innovations. Manuscripts addressing challenges and techniques to decrease adverse events and improve outcomes will be considered. We also invite case reports and series followed by a discussion that may stimulate the creation of new hypotheses and the advent of new research.

Dr. Shyam K. Sathanandam
Prof. Dr. Jeffrey A. Towbin
Prof. Ranjit Philip
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Prematurity
  • Transcutaneous interventions
  • Patent ductus arteriosus
  • Pulmonary hypertension
  • Ventricular assist device

Published Papers (3 papers)

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Research

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Article
Respiratory Trajectory after Invasive Interventions for Patent Ductus Arteriosus of Preterm Infants
Children 2021, 8(5), 398; https://doi.org/10.3390/children8050398 - 15 May 2021
Cited by 1 | Viewed by 528
Abstract
Invasive interventions have been conducted in preterm infants with significant patent ductus arteriosus (PDA) when medical treatment has failed, and methods of invasive intervention have been reported. Surgical ligation via lateral thoracotomy has been a well-established procedure for decades. Recently, transcatheter occlusion has [...] Read more.
Invasive interventions have been conducted in preterm infants with significant patent ductus arteriosus (PDA) when medical treatment has failed, and methods of invasive intervention have been reported. Surgical ligation via lateral thoracotomy has been a well-established procedure for decades. Recently, transcatheter occlusion has been safely and feasibly applied to the premature population. However, little research has been conducted on the benefits of transcatheter occlusion in very-low-birth-weight (VLBW) infants compared to surgical ligation. This study compared transcatheter and surgical techniques in VLBW infants in terms of short-term respiratory outcomes. The medical records of 401 VLBW infants admitted to a tertiary hospital between September 2014 and January 2019 were retrospectively reviewed. Patients who were diagnosed with a congenital anomaly, a chromosomal anomaly, or congenital heart disease, except for an inter-atrial shunt, were excluded. The perinatal conditions, neonatal morbidities, periprocedural vital signs, and respiratory support trajectories were compared between the transcatheter-treated and surgically ligated group. A total of 31 eligible VLBW infants received invasive intervention: 14 were treated with transcatheter occlusion (Group A), and 17 infants were treated with surgical ligation (Group B). Respiratory outcomes were not statistically significant between the two groups, despite Group A showing a trend toward early improvement in post-intervention respiratory trajectory. In this small case study, a different trend in post-intervention respiratory trajectories was observed. Future research with larger case numbers should be conducted to address our preliminary observations in more detail. Full article
(This article belongs to the Special Issue Advances in Pediatric Heart Disease Research—Neonatal Interventions)
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Review

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Review
Single Ventricle—A Comprehensive Review
Children 2021, 8(6), 441; https://doi.org/10.3390/children8060441 - 24 May 2021
Cited by 1 | Viewed by 506
Abstract
In this paper, the author enumerates cardiac defects with a functionally single ventricle, summarizes single ventricle physiology, presents a summary of management strategies to address the single ventricle defects, goes over the steps of staged total cavo-pulmonary connection, cites the prevalence of inter-stage [...] Read more.
In this paper, the author enumerates cardiac defects with a functionally single ventricle, summarizes single ventricle physiology, presents a summary of management strategies to address the single ventricle defects, goes over the steps of staged total cavo-pulmonary connection, cites the prevalence of inter-stage mortality, names the causes of inter-stage mortality, discusses strategies to address the inter-stage mortality, reviews post-Fontan issues, and introduces alternative approaches to Fontan circulation. Full article
(This article belongs to the Special Issue Advances in Pediatric Heart Disease Research—Neonatal Interventions)
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Other

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Perspective
Statistical Treatment of Clinical Investigations in Pediatric Cardiology
Children 2021, 8(4), 296; https://doi.org/10.3390/children8040296 - 12 Apr 2021
Viewed by 444
Abstract
This paper describes various statistical methods used by the author during multiple studies conducted by the author. Initially, the data were scrutinized to ensure normal distribution, and expressed as mean ± standard deviation (SD) or standard error of mean (SEM) for normally distributed [...] Read more.
This paper describes various statistical methods used by the author during multiple studies conducted by the author. Initially, the data were scrutinized to ensure normal distribution, and expressed as mean ± standard deviation (SD) or standard error of mean (SEM) for normally distributed variables. Medians and ranges were given for the data with skewed distribution. Two tailed, paired t tests or independent sample t tests (analysis of variance) were used for normally distributed data, while non-parametric chi-square or similar other tests were utilized for data with skewed distribution. Statistical significance was set at a p value of < 0.05. Bonferroni correction was applied when the study involves multiple comparisons. A number of other statistical methods used during these studies were also discussed. Finally, special methods used in evaluating aortic remodeling subsequent to balloon angioplasty of native aortic coarctation were reviewed. Full article
(This article belongs to the Special Issue Advances in Pediatric Heart Disease Research—Neonatal Interventions)
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