Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Immune Responsiveness in the Era of T Cell Immunotherapy
edited by and
submission deadline 30 Jan 2026 | Viewed by 204 | Submission Open
Keywords: T cell-mediated immunity; cancer immune responsiveness; cytokine modulation
Ubiquitin Ligases in Health and Diseases
edited by Haitao Luan
submission deadline 30 Jan 2026 | Viewed by 110 | Submission Open
Keywords: ubiquitination; E3 ubiquitin ligase; Proteasome; protein degradation; cell cycle regulation; immune response; neurodegeneration; cancer; autoimmune disorders; therapeutic targeting
(This special issue belongs to the Section Cell Signaling)
Advanced Technology for Cellular Imaging
edited by Alessandro Grinzato, and
submission deadline 31 Jan 2026 | 9 articles | Viewed by 21624 | Submission Open
Keywords: electron tomography; fluorescence microscopy; live cell imaging; multimodal imaging; super resolution microscopy; cell– cell interaction
(This special issue belongs to the Section Cell Methods)
Molecular and Cellular Mechanisms of Cardiovascular and Metabolic Diseases
edited by
submission deadline 31 Jan 2026 | 7 articles | Viewed by 20260 | Submission Open
Keywords: mitochondrial dysfunction; endoplasmic reticulum (ER) stress; oxidative/nitrosative stress; diabetes; obesity; diet; atherosclerosis; hypertension; metabolomics; cell death; nutraceuticals/functional foods
(This special issue belongs to the Section Cells of the Cardiovascular System)
Neuroinflammation in Brain Health and Diseases
edited by Debashis Dutta and Nemil Bhatt
submission deadline 31 Jan 2026 | 9 articles | Viewed by 15969 | Submission Open
Keywords: neuroinflammation; gliosis; inflammasome; neurodegeneration; neurotherapeutics
(This special issue belongs to the Section Cellular Neuroscience)
Imaging Methods in Cell Biology submission deadline 31 Jan 2026 | 6 articles | Viewed by 15689 | Submission Open
Keywords: cellular organelles; molecular function; molecular interaction; disease- and drug-related subcellular phenomena; single-molecule imaging; light microscopy; electron microscopy; fluorescence microscopy; fluorescence correlation methods; fluorescence lifetime imaging microscopy (FLIM); Raman microscopy; spatial biology
(This special issue belongs to the Section Cell Methods)
Cancer-Associated Fibroblasts: Challenges and Directions submission deadline 31 Jan 2026 | 5 articles | Viewed by 15655 | Submission Open
Keywords: cancer-associated fibroblast (CAFs); tumor microenvironment (TME); fibroblast activation protein alpha (FAPα ); immunotherapy; cytokines; angiogenesis; metastasis; FAP inhibitors; radioligands; imaging agents
(This special issue belongs to the Section Cell Microenvironment)
Emerging Targets and Therapeutic Potential Drugs in Tumor Progression and Therapeutic Resistance
edited by , and Yuancheng Li
submission deadline 31 Jan 2026 | 3 articles | Viewed by 6793 | Submission Open
Keywords: cancer; tumor progression; therapeutic resistance; molecular targets; tumor microenvironment; innovative therapies; targeted drug delivery; natural product
(This special issue belongs to the Section Cell Microenvironment)
Renewing Reasons to Believe in Gene Therapies for Epilepsy
edited by Casper Gøtzsche
submission deadline 31 Jan 2026 | 2 articles | Viewed by 6176 | Submission Open
Keywords: epilepsy; seizure; gene therapy; gene editing; disease modification; transformative; unmet need
(This special issue belongs to the Section Cellular Neuroscience)
CRISPR-Based Genome Editing in Translational Research—Third Edition
edited by , and Jifeng Zhang
submission deadline 31 Jan 2026 | 3 articles | Viewed by 5542 | Submission Open
Keywords: genome; gene editing; CRISPR/Cas9
Neuro-Oncological Advances in Stem Cell Research: A New Era in Brain Tumor Therapy submission deadline 31 Jan 2026 | 2 articles | Viewed by 3496 | Submission Open
Keywords: brain tumor genetics and epigenetics; brain tumor stem cells; stem cell therapy against brain tumors; mesenchymal stem cells; iPSC; resistance to therapy
(This special issue belongs to the Section Stem Cells)
New Advances in Tissue Engineering and Regeneration submission deadline 31 Jan 2026 | 1 articles | Viewed by 2321 | Submission Open
Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research
(This special issue belongs to the Section Tissues and Organs)
Novel Therapeutic Strategies to Improve Mitochondrial Function in Neurodegenerative Diseases
edited by Patricia Morcillo
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2167 | Submission Open
Keywords: mitochondria; cellular signaling; neurodegenerative diseases; mitochondrial dynamics; organelles; neurological diseases; therapies; biomarkers
(This special issue belongs to the Section Cellular Aging)
Cell Behavior Under Blood Flow
edited by Alexander Gural, Ivana Pajic-Lijakovic and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1532 | Submission Open
Keywords: blood flow; shear stress; red blood cells; white blood cells; platelets; endothelial cells; cell stimulation; mechanical stress
The Role of Macrophages in Leishmaniasis: Current Perspective
edited by Devki Nandan
submission deadline 31 Jan 2026 | 1 articles | Viewed by 932 | Submission Open
Keywords: Leishmania; leishmaniasis; macrophage biology; host– pathogen interactions
Cellular and Molecular Mechanisms in Immune Regulation—Second Edition
edited by Fábio Rinaldo Santori and Natalia B. Ivanova
submission deadline 31 Jan 2026 | 2 articles | Viewed by 588 | Submission Open
Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy
(This special issue belongs to the Section Cellular Pathology)
Autophagy and Neurodegeneration: Unveiling Cellular Pathways in ALS and Beyond
edited by Valeria Gerbino
submission deadline 31 Jan 2026 | 1 articles | Viewed by 565 | Submission Open
Keywords: autophagy; neurodegeneration; amyotrophic lateral sclerosis (ALS); protein aggregation; cellular homeostasis; lysosomal dysfunction; neuronal health; therapeutic targets; molecular pathways; neuroprotective strategies
(This special issue belongs to the Section Cellular Neuroscience)
Acute Myeloid Leukemia: Unraveling Molecular Drivers, Cellular Plasticity, and Therapeutic Vulnerabilities
edited by Fabio Guolo
submission deadline 31 Jan 2026 | 1 articles | Viewed by 438 | Submission Open
Keywords: acute myeloid leukemia (AML); hematologic malignancy; AML classification; myeloid precursors; hematopoiesis; high-risk AML; biomarkers
(This special issue belongs to the Section Cellular Immunology)
Single-Molecule Tracking for Live Cells
edited by
submission deadline 31 Jan 2026 | Viewed by 364 | Submission Open
Keywords: single-molecule level; many-molecule level; biological cell; diluted liquids; single-molecule localization microscopy; nanoscopy; modeling; diffusion; theory
Diagnostic and Therapeutic Application of Extracellular Vesicles (EV) submission deadline 31 Jan 2026 | Viewed by 311 | Submission Open
Keywords: extracellular vesicles (EVs); diseases biomarkers; therapeutic targets; drugs delivery; engineered extracellular vesicles; EVs therapeutic applications
Mechanisms That Link Olfactory Perception with Aging
edited by , Anindya Ganguly and Jordan A. Munroe
submission deadline 31 Jan 2026 | Viewed by 296 | Submission Open
Keywords: olfaction; aging; neuroscience
(This special issue belongs to the Section Cellular Aging)
Human Organoids: A New Frontier in Disease Modeling
edited by and Umesh Kumar
submission deadline 31 Jan 2026 | Viewed by 207 | Submission Open
Keywords: 3D organ culture; embryonic stem cells; induced pluripotent stem cells; 3D bioprinting; personalized medicine; regenerative medicine
(This special issue belongs to the Section Tissues and Organs)
Gastrointestinal Disorders: Immunity and Inflammation
edited by Faizan Ahmed and
submission deadline 31 Jan 2026 | Viewed by 205 | Submission Open
Keywords: gastrointestinal disorders; immunity; inflammation; immune system; microbiota; gastroenterology; biomarkers; pathways
Genetics and Gene Regulation
edited by and
submission deadline 31 Jan 2026 | Viewed by 179 | Submission Open
Keywords: genetics; gene regulation; human diseases
New Trends and Advances in Molecular Targeted Therapy for Cancers
edited by Dhivya Sridaran and
submission deadline 31 Jan 2026 | Viewed by 172 | Submission Open
Keywords: cancer targeted therapy; antibodies; small-molecule inhibitors; antibody– drug conjugates; combination therapies
(This special issue belongs to the Section Cell and Gene Therapy)
Function of Stress Granules in Normal Cells and in Alzheimer’s Disease
edited by and Benjamin Wolozin
submission deadline 31 Jan 2026 | Viewed by 154 | Submission Open
Keywords: stress granules; Alzheimer's disease; neurodegenerative diseases
(This special issue belongs to the Section Cellular Aging)
New Perspectives of Respiratory Diseases: From Microbiome, Metabolism, and Immune Response
edited by
submission deadline 31 Jan 2026 | Viewed by 151 | Submission Open
Keywords: cell death/stress; DNA/RNA sensor; cGAS/STING; inflammasome; microbiome; FMT or transfer of bacteria; metabolite; viral infection; emphysema; progressive fibrosis; innate immune response; defined inhibitors
Aquaporins at the Crossroads of Human Health and Disease
edited by
submission deadline 31 Jan 2026 | Viewed by 149 | Submission Open
Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics
Examining the Cellular Biology of Adenovirus
edited by Susan J. Morris, Adam C. T. Gillman and Erwan Sallard
submission deadline 31 Jan 2026 | Viewed by 141 | Submission Open
Keywords: adenovirus; replication; maturation; transduction; tropism; intracellular trafficking; targeting; virus– host interactions; transcriptome
The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders
edited by , and Adriana C. E. Graziano
submission deadline 31 Jan 2026 | Viewed by 118 | Submission Open
Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation
(This special issue belongs to the Section Cellular Neuroscience)
Biochemical Mechanisms and Physiological Implication of Stem Cell Differentiation submission deadline 31 Jan 2026 | Viewed by 116 | Submission Open
Keywords: stem cells; differentiation; 3D cultures; co-cultures; biochemistry; physiology; epigenetics
(This special issue belongs to the Section Stem Cells)
Role of Oxidative Stress in Cardiovascular Diseases submission deadline 31 Jan 2026 | Viewed by 71 | Submission Open
Keywords: oxidative stress; reactive oxygen species (ROS); endothelial dysfunction; inflammation; cardiovascular pathology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Advances in the Role of Lipid Signaling in Diseases
edited by and
submission deadline 5 Feb 2026 | Viewed by 189 | Submission Open
Keywords: lipid signaling; membrane lipid dynamics; autophagy; disease pathology; mitochondria; transcription; protein degradation
Role of Alpha-Synuclein in Neurodegenerative Diseases
edited by
submission deadline 10 Feb 2026 | 1 articles | Viewed by 1423 | Submission Open
Keywords: Alpha-; Beta-; and Gamma-synuclein; synucleinopathies; neurodegeneration; neuroinflammation; authophagy; Parkinson's disease; non-motor symptoms; Alzheimer's disease; multiple system atrophy; psychiatric diseases
(This special issue belongs to the Section Cellular Aging)
Decoding Cellular Organization Through Spatial Omics
edited by Elizabeth Neumann
submission deadline 10 Feb 2026 | Viewed by 165 | Submission Open
Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology
Exclusive Review Papers in Autophagy—Second Edition
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 18988 | Submission Open
Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades
(This special issue belongs to the Section Autophagy)
Cancer Immunotherapy Harnessing Innate and Adaptive Immune Effector Cells and PD-1 Immune Checkpoint Inhibitors
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 14392 | Submission Open
Keywords: PD-1 immune checkpoint; CAR-T cells; γ δ T cells; NK cells
(This special issue belongs to the Section Cellular Immunology)
State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)
edited by
submission deadline 15 Feb 2026 | 4 articles | Viewed by 10222 | Submission Open
Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
Molecular Therapeutic Advances for Neurodegenerative Diseases
edited by
submission deadline 15 Feb 2026 | 3 articles | Viewed by 5533 | Submission Open
Keywords: neurodegenerative diseases; neurodegeneration; neurological disorders
(This special issue belongs to the Section Cellular Aging)
Spotlight on Natural Killer Cells in Immuno-Oncology submission deadline 15 Feb 2026 | 1 articles | Viewed by 3656 | Submission Open
Keywords: natural killer (NK) cells; cancer stem cells (CSCs); poorly differentiated tumors; differentiation; aggressive tumors; suppressor cells
(This special issue belongs to the Section Cellular Immunology)
Epigenetic Mechanisms of Tumorigenesis
edited by
submission deadline 15 Feb 2026 | 1 articles | Viewed by 1871 | Submission Open
Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine
Cancers and Metabolic Diseases—the Molecular Players in the Game
edited by
submission deadline 15 Feb 2026 | Viewed by 138 | Submission Open
Keywords: metabolism; bioenergetics; signaling; cytokines; molecular; mechanisms; receptors; design; therapeutics
GPCR Signaling in PDA: Calcium, cAMP, and Ras Activation in Pancreatic Ductal Adenocarcinoma
edited by
submission deadline 15 Feb 2026 | Viewed by 117 | Submission Open
Keywords: G protein-coupled receptor (GPCR); receptor tyrosine kinases (RTK); oncogenic Kras; pancreatic ductal adenocarcinoma (PDA); epigenetic regulation; Wnt and Hedgehog (HH); second messengers (cAMP and intracellular calcium); acinar to ductal metaplasia (ADM); tumor microenvironment; therapeutic drugs list of solicited contributors
Cellular Mechanisms and Therapies of Hematologic Malignancies
edited by Sayantani Sinha and Stanley Chun-Wei Lee
submission deadline 15 Feb 2026 | Viewed by 88 | Submission Open
Keywords: AML; ALL and CLL; targeted therapy; combination therapy; small molecule inhibitors; immunotherapy; RNA in hematopoiesis; overcoming resistance
(This special issue belongs to the Section Cellular Pathology)
Phosphodiesterases (PDEs): Therapeutic Targets in Human Health and Disease
edited by , , Michy P. Kelly and Leila Gobejishvili
submission deadline 20 Feb 2026 | 17 articles | Viewed by 48983 | Submission Open
Keywords: cyclic nucleotide phosphodiesterase; PDE; cAMP; cGMP; signal transduction
(This special issue belongs to the Section Cell Microenvironment)
Motor Neuron Diseases: From Molecular Basic Research to Diagnosis and Therapeutics Implications
edited by and Elisabetta Zucchi
submission deadline 20 Feb 2026 | 5 articles | Viewed by 11906 | Submission Open
Keywords: motor neuron; genetics; oxidative stress; misfolded protein aggregates; biomarkers; gene therapy
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth
edited by Khondoker M. Akram
submission deadline 20 Feb 2026 | 3 articles | Viewed by 7748 | Submission Open
Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth
(This special issue belongs to the Section Cellular Pathology)
Ovarian Cancer and Endometriosis
edited by and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4236 | Submission Open
Keywords: ovarian cancer; endometriosis; microenvironment; cell-cell interaction; drug resistance; natural product
(This special issue belongs to the Section Cellular Pathology)
T Cells in Inflammation and Cancer
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3493 | Submission Open
Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy
(This special issue belongs to the Section Cellular Immunology)
Molecular Mechanisms of Leukemias
edited by and Frode Selheim
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2115 | Submission Open
Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML)
(This special issue belongs to the Section Cellular Pathology)
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