Special Issue "Yeast as a Model in Aging Research"

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editors

Assoc. Prof. Milena Georgieva
E-Mail Website1 Website2
Guest Editor
Laboratory of Yeast Molecular Genetics, Institute of Molecular Biology “Roumen Tsanev”, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
Interests: cellular ageing; molecular biology and genetics; epigenetics; nuclear structure and function; chromatin; linker histones; yeast genetics; cancer biology; genotoxicology; nanotoxicology
Dr. Mateusz Mołoń
E-Mail Website
Guest Editor
Department of Biochemistry and Cell Biology, Institute of Biology and Biotechnology, University of Rzeszów, Zelwerowicza 4 Street, 35-601 Rzeszów, Poland
Interests: aging; cell cycle regulation; longevity; yeast biology

Special Issue Information

Dear Colleagues,

Aging is an inevitable, complex and multifactorial process leading to loss of cells, tissues, and organismal functions. Despite years of studies and research efforts, the precise molecular mechanisms and the main determinants of aging are yet to be found. Use of simple models is fundamental in basic research because molecular mechanisms that regulate most cellular processes are highly conserved between mammals and simple eukaryotes. Yeast as a model organism has been used as a workhorse in many areas of science, including aging. In yeast, as in other models, there are private and public factors that determine aging. Therefore, for this issue, we invite manuscripts focused on the intricate mechanisms of aging based on the yeast model. This Special Issue under the broad theme of Yeast as a model for aging research intends to explore and reveal the latest significant advances towards identifying unknown molecular mechanisms that determine cellular aging, longevity and cell death. Studies based on yeast model organisms, such as Saccharomyces cerevisiae, and nonconventional yeasts are welcome. Focused review articles as well as original research papers are sought contributions.

Assoc. Prof. Milena Georgieva
Dr. Mateusz Mołoń
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • aging
  • antioxidants
  • apoptosis
  • cell death
  • lifespan
  • longevity
  • chromatin
  • genome instability
  • yeast
  • oxidative stress
  • DNA damage

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Chronological aging in yeast
Authors: Mario G. Mirisola1 and Valter D. Longo2
Affiliation: 1 DiChirOnS Dept. University if Palermo, Palermo, ITALY, 2 Longevity Institute, University of Southern California (USC) LA USA
Abstract: /

Title: Linker histones as guardians of the genome are involved in the processes of ageing
Authors: George Miloshev
Affiliation: /
Abstract: /

Title: Changes in chromatin organization abolish mitochondrial functions and lead to premature ageing phenotypes
Authors: Bela Vasileva1, Dessislava Staneva1, Petar Podlesniy2, Ramon Trullas2, Natalia Krasteva3, George Miloshev1 and Milena Georgieva1
Affiliation: 1. Laboratory of Yeast Molecular Genetics, Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria 2. Institut d'Investigacions Biomèdiques de Barcelona: Institut d'Investigacions Biomediques de Barcelona 3. Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria

Title: The molecular mechanism of programmed cell death in yeast
Authors: Chang-Hui Shen
Affiliation: Department of Biology, College of Staten Island, City University of New York

Title: Yeast as a model for Cancer research
Authors: Paola Fabrizio
Affiliation: /
Abstract: /

Title: related to aging research in Podospora anserina
Authors: Osiewacz et al
Affiliation: Institute for Molecular Biology, Goethe University
Abstract: /

Title: Identification of tropical plant extracts that extend yeast chronological lifespan
Authors: Mandy Mun Yee Kwong a,b, Jee Whu Leea,b, Tee Gee Onga,b, Mohammed Razip Samianb,c, Habibah A Wahab b,d, Nobumoto Watanabeb,e, Hiroyuki Osadab,f and Eugene Boon Beng Onga,b,*
Affiliation: a Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia b USM-RIKEN International Centre for Ageing Science (URICAS) c School of Biological Sciences, Universiti Sains Malaysia d School of Pharmaceutical Sciences, Universiti Sains Malaysia e Bioprobe Application Research Unit, RIKEN Centre for Sustainable Resource Science, RIKEN, Japan f Chemical Biology Research Group, RIKEN Centre for Sustainable Resource Science, RIKEN, Japan
Abstract: /

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