Mechanics of Stem Cells in Regenerative Medicine

Dear Colleagues,

Tissue and organ failure are becoming a major health problem around the world. To this end, pluripotent stem cells can provide unlimited cell supply in a laboratory setting for cell-based therapy. However, cell lineage control can become a limiting factor. Past studies have demonstrated pluripotent stem cell lineage specification via small molecules and/or physical factors including mechanical forces, microenvironment properties, extracellular matrix, surface topography, geometric regulations, etc. In particular, physical forces, whether endogenously generated or externally applied, play a vital role in cell fate decisions. Recent developments in single-molecule techniques may allow force modulation with a pico-Newton resolution that can be applied in stem cell fate decision making. Further research is necessary to understand the underlying mechanisms of cell lineage specification for application in regenerative medicine.

In this Special Issue, we welcome both original works as well as review articles related to the mechanics of pluripotent stem cells in regenerative medicine. In addition, studies focused on multipotent stem cells in regenerative medicine are welcome.

Dr. Farhan Chowdhury
Guest Editor

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