Redox Control of Cell Signaling in Cardiac and Skeletal Muscle

Dear Colleagues,

The observation that contracting skeletal muscles produce reactive oxygen species (ROS) was reported approximately 40 years ago. This landmark finding provided the impetus for a new field of life science investigation—muscle redox biology. Since this milestone discovery, significant advancements have occurred in our understanding of the influence that ROS and reactive nitrogen species have on cardiac and skeletal muscle contractile function and cell signaling pathways. Interestingly, oxidant production within cardiac and skeletal muscle fibers is a double-edged sword. Indeed, the continuous production of high levels of ROS results in pathological injury in muscle fibers, whereas transient and low-level ROS production within muscle fibers triggers cell signaling pathways that lead to hormetic adaptation.

Because of the recent and rapid growth of knowledge in muscle redox biology, the objective of this Special Issue of Cells is to provide both original research and state-of-the-art reviews on the latest findings linked to muscle redox biology. Therefore, this Special Issue is designed to cover broad aspects of these important scientific areas, with a primary focus on cellular events. Nonetheless, this Special Issue will also address the physiological and pathological aspects of redox events that impact the function of intact cardiac and skeletal muscle fibers.

Prof. Dr. Scott Powers
Prof. Dr. Li Li Ji
Prof. Dr. Michael Reid
Guest Editors

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