Microglia in Aging and Neurodegenerative Diseases

Dear Colleagues,

It is now well accepted that the immune system and the central nervous system (CNS) dynamically interact in both physiological and pathological conditions and that neuroinflammation and immune molecules have the potential to influence the induction of CNS plasticity, learning, cognition and recovery processes.

During brain aging or in certain pathological conditions, this crosstalk can go beyond physiological control. The inflammatory process in the brain, accompanied by the presence of activated microglia, has recently gained much attention in several degenerative neurological diseases, including, but not limited to, Alzheimer’s and Parkinson’s diseases. While activated microglia may promote neuronal degeneration or neuroprotection, its precise role has not been clarified yet.

In this Topical Collection of Cells, I invite you to contribute, either in the form of original research articles, reviews, or shorter perspective articles on all aspects of the theme “Microglia in Aging and Neurodegenerative Diseases”. Expert articles describing mechanistic, functional, cellular, biochemical, or general aspects of microglial contribution in normal brain aging or neurodegeneration are highly welcome. Relevant topics include, but are not limited to

• Cytokine signaling
• Chemokine function
• In vitro and in vivo models
• Morphological characterizations
• Electrophysiological changes
• Inflammation
• Bioimaging
• Behavioral analysis
• Translational medicine

Dr. Alessandro Tozzi
Collection Editor

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