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Cells 2018, 7(5), 43; https://doi.org/10.3390/cells7050043

Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture

Department of Surgery, Royal College of Surgeons in Ireland, RCSI Smurfit Building, Beaumont Hospital, Dublin 9, Ireland
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Received: 12 March 2018 / Revised: 9 May 2018 / Accepted: 11 May 2018 / Published: 16 May 2018
(This article belongs to the Special Issue Cell Adhesion Molecules)
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Abstract

Although the developments in cellular and molecular biology over the last few decades have significantly advanced our understanding of the processes and players that regulate invasive disease, many areas of uncertainty remain. This review will discuss the contribution of dysregulated cell–cell and cell–matrix adhesion to the invasion in both benign and malignant contexts. Using the endometrium as an illustrative tissue that undergoes clinically significant invasion in both contexts, the adhesion considerations in the cells (“seed”) and their microenvironment (“soil”) will be discussed. We hope to orientate this discussion towards translational relevance for the diagnosis and treatment of endometrial conditions, which are currently associated with significant morbidity and mortality. View Full-Text
Keywords: adhesion; ICAM-1; VCAM-1; integrins; endometrium; endometriosis; endometrial cancer; microenvironment; inflammation; seed and soil; biomarkers adhesion; ICAM-1; VCAM-1; integrins; endometrium; endometriosis; endometrial cancer; microenvironment; inflammation; seed and soil; biomarkers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Rutherford, E.J.; Hill, A.D.K.; Hopkins, A.M. Adhesion in Physiological, Benign and Malignant Proliferative States of the Endometrium: Microenvironment and the Clinical Big Picture. Cells 2018, 7, 43.

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