Special Issue "Translational Regulation of Biological Processes"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 April 2020) | Viewed by 5595
2. Department of Pathology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
3. Department of Pathology, Neuropathology, and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria
4. Center for Biomarker Research in Medicine, Graz, Austria; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany
A dysregulation of protein biosynthesis is now considered a hallmark of several diseases, including cancer. Changes in protein synthesis are a crucial factor in establishing the cellular proteome, hence controlling cell proliferation, differentiation, and development, and thus, the progression of aging, age-related diseases and cancer.
An important limiting factor for protein biosynthesis is the initiation of translation. This process comprises a highly organized sequence of interactions between the structural features of mRNA and eukaryotic translation initiation factors. These interactions are regulated by a number of molecular switches, often regulated by signaling pathways that are well-known drivers of carcinogenesis. Translation initiation factors do not only regulate translation in a quantitative manner but also influence qualitative changes in mRNA translation; recent evidence shows that they can even control mRNA splicing.
In this Special Issue, we would like to invite researchers to present studies on the dysregulation of translation initiation and other issues on translational control and its effects on carcinogenesis but also other biological processes. We particularly encourage the submission of original research papers dealing with, but not restricted to, the influence of translation on the molecular mechanisms of regulation and assembly of eukaryotic initiation factor–mRNA complexes and how this alters cellular physiology. Additionally, papers are invited providing evidence that translation initiation may represent a promising therapeutic target for therapy. We also welcome review articles describing our current knowledge of the regulation of translation and its role in physiologic and pathologic processes.
Prof. Dr. Johannes Haybaeck
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