Next Article in Journal
The RNA Replication Site of Tula Orthohantavirus Resides within a Remodelled Golgi Network
Previous Article in Journal
mTORC2 Is Involved in the Induction of RSK Phosphorylation by Serum or Nutrient Starvation
Previous Article in Special Issue
The Drosophila RNA Helicase Belle (DDX3) Non-Autonomously Suppresses Germline Tumorigenesis Via Regulation of a Specific mRNA Set
Open AccessReview

Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase

Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, Rumburska 89, 27721 Libechov, Czech Republic
Author to whom correspondence should be addressed.
Cells 2020, 9(7), 1568;
Received: 28 April 2020 / Revised: 15 June 2020 / Accepted: 24 June 2020 / Published: 27 June 2020
(This article belongs to the Special Issue Translational Regulation of Biological Processes)
Cyclin dependent kinase 1 (CDK1) has been primarily identified as a key cell cycle regulator in both mitosis and meiosis. Recently, an extramitotic function of CDK1 emerged when evidence was found that CDK1 is involved in many cellular events that are essential for cell proliferation and survival. In this review we summarize the involvement of CDK1 in the initiation and elongation steps of protein synthesis in the cell. During its activation, CDK1 influences the initiation of protein synthesis, promotes the activity of specific translational initiation factors and affects the functioning of a subset of elongation factors. Our review provides insights into gene expression regulation during the transcriptionally silent M-phase and describes quantitative and qualitative translational changes based on the extramitotic role of the cell cycle master regulator CDK1 to optimize temporal synthesis of proteins to sustain the division-related processes: mitosis and cytokinesis. View Full-Text
Keywords: CDK1; 4E-BP1; mTOR; mRNA; translation; M-phase CDK1; 4E-BP1; mTOR; mRNA; translation; M-phase
Show Figures

Figure 1

MDPI and ACS Style

Kalous, J.; Jansová, D.; Šušor, A. Role of Cyclin-Dependent Kinase 1 in Translational Regulation in the M-Phase. Cells 2020, 9, 1568.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop