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2′O-Ribose Methylation of Ribosomal RNAs: Natural Diversity in Living Organisms, Biological Processes, and Diseases

Inserm U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Université de Lyon, Université Claude Bernard Lyon 1, Centre Léon Bérard, CEDEX 08, F-69373 Lyon, France
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Academic Editor: Alexander E. Kalyuzhny
Cells 2021, 10(8), 1948; https://doi.org/10.3390/cells10081948
Received: 2 July 2021 / Revised: 28 July 2021 / Accepted: 29 July 2021 / Published: 31 July 2021
(This article belongs to the Special Issue Translational Regulation of Biological Processes)
Recent findings suggest that ribosomes, the translational machineries, can display a distinct composition depending on physio-pathological contexts. Thanks to outstanding technological breakthroughs, many studies have reported that variations of rRNA modifications, and more particularly the most abundant rRNA chemical modification, the rRNA 2′O-ribose methylation (2′Ome), intrinsically occur in many organisms. In the last 5 years, accumulating reports have illustrated that rRNA 2′Ome varies in human cell lines but also in living organisms (yeast, plant, zebrafish, mouse, human) during development and diseases. These rRNA 2′Ome variations occur either within a single cell line, organ, or patient’s sample (i.e., intra-variability) or between at least two biological conditions (i.e., inter-variability). Thus, the ribosomes can tolerate the absence of 2′Ome at some specific positions. These observations question whether variations in rRNA 2′Ome could provide ribosomes with particular translational regulatory activities and functional specializations. Here, we compile recent studies supporting the heterogeneity of ribosome composition at rRNA 2′Ome level and provide an overview of the natural diversity in rRNA 2′Ome that has been reported up to now throughout the kingdom of life. Moreover, we discuss the little evidence that suggests that variations of rRNA 2′Ome can effectively impact the ribosome activity and contribute to the etiology of some human diseases. View Full-Text
Keywords: 2′-O-methylation; rRNA modification; ribosome; ribosome heterogeneity; RiboMeth-seq 2′-O-methylation; rRNA modification; ribosome; ribosome heterogeneity; RiboMeth-seq
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MDPI and ACS Style

Jaafar, M.; Paraqindes, H.; Gabut, M.; Diaz, J.-J.; Marcel, V.; Durand, S. 2′O-Ribose Methylation of Ribosomal RNAs: Natural Diversity in Living Organisms, Biological Processes, and Diseases. Cells 2021, 10, 1948. https://doi.org/10.3390/cells10081948

AMA Style

Jaafar M, Paraqindes H, Gabut M, Diaz J-J, Marcel V, Durand S. 2′O-Ribose Methylation of Ribosomal RNAs: Natural Diversity in Living Organisms, Biological Processes, and Diseases. Cells. 2021; 10(8):1948. https://doi.org/10.3390/cells10081948

Chicago/Turabian Style

Jaafar, Mariam, Hermes Paraqindes, Mathieu Gabut, Jean-Jacques Diaz, Virginie Marcel, and Sébastien Durand. 2021. "2′O-Ribose Methylation of Ribosomal RNAs: Natural Diversity in Living Organisms, Biological Processes, and Diseases" Cells 10, no. 8: 1948. https://doi.org/10.3390/cells10081948

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