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Neurovascular Inflammaging in Health and Disease

1
Institute of Biophysics, Biological Research Centre, 6726 Szeged, Hungary
2
Doctoral School of Biology, University of Szeged, 6726 Szeged, Hungary
3
Theoretical Medicine Doctoral School, University of Szeged, 6720 Szeged, Hungary
4
Foundation for the Future of Biomedical Sciences in Szeged, Szeged Scientists Academy, 6720 Szeged, Hungary
5
Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Oklahoma Center for Geroscience, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
6
Institute of Life Sciences, Vasile Goldiş Western University of Arad, 310414 Arad, Romania
*
Author to whom correspondence should be addressed.
Cells 2020, 9(7), 1614; https://doi.org/10.3390/cells9071614
Received: 22 June 2020 / Accepted: 2 July 2020 / Published: 4 July 2020
(This article belongs to the Special Issue Roles of Inflammasomes in Aging and Age-Related Diseases)
Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These, acting as danger signals with many intrinsic factors such as cytokines, are sensed by a network of pattern recognition receptors and other cognate receptors, leading to the activation of inflammasomes. Due to the inflammasome activity-dependent increase in the levels of pro-inflammatory interleukins (IL-1β, IL-18), inflammation is initiated, resulting in tissue injury in various organs, the brain and the spinal cord included. Similarly, in age-related diseases of the central nervous system (CNS), inflammasome activation is a prominent moment, in which cells of the neurovascular unit occupy a significant position. In this review, we discuss the inflammatory changes in normal aging and summarize the current knowledge on the role of inflammasomes and contributing mechanisms in common CNS diseases, namely Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and stroke, all of which occur more frequently with aging. View Full-Text
Keywords: aging; inflammaging; inflammasome; neurodegeneration; neuroinflammation; neurovascular unit; stroke aging; inflammaging; inflammasome; neurodegeneration; neuroinflammation; neurovascular unit; stroke
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MDPI and ACS Style

Mészáros, Á.; Molnár, K.; Nógrádi, B.; Hernádi, Z.; Nyúl-Tóth, Á.; Wilhelm, I.; Krizbai, I.A. Neurovascular Inflammaging in Health and Disease. Cells 2020, 9, 1614. https://doi.org/10.3390/cells9071614

AMA Style

Mészáros Á, Molnár K, Nógrádi B, Hernádi Z, Nyúl-Tóth Á, Wilhelm I, Krizbai IA. Neurovascular Inflammaging in Health and Disease. Cells. 2020; 9(7):1614. https://doi.org/10.3390/cells9071614

Chicago/Turabian Style

Mészáros, Ádám, Kinga Molnár, Bernát Nógrádi, Zsófia Hernádi, Ádám Nyúl-Tóth, Imola Wilhelm, and István A. Krizbai 2020. "Neurovascular Inflammaging in Health and Disease" Cells 9, no. 7: 1614. https://doi.org/10.3390/cells9071614

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