Role of Non-coding RNA in Health and Disease

Dear Colleagues,

The discovery of RNA interference eventually led to the elucidation of new mechanisms in the cell and the discovery of new mechanisms of gene expression regulation by various noncoding RNA molecules. For example, long noncoding RNAs, microRNAs, and circular RNAs have aroused the curiosity of researchers due to their generation mechanism alone. To date, a variety of unimaginable intracellular regulations have been revealed, including their intracellular action mechanisms and related gene networks.

Recently, it has become clear that these noncoding RNAs play an important role in disease causation and malignant transformation and are attracting attention not only as biomarkers of disease, but also as therapeutic targets. In particular, as the pathways of genes involved in noncoding RNAs are clarified, the findings that were known before the discovery of noncoding RNAs are being found to be related to one another. Based on these findings, the treatment of diseases by regulating the network of genes involved in noncoding RNAs is now within reach. In this context, we are proposing this Special Issue to focus on the relationship between noncoding RNAs and health maintenance and diseases.

This Special Issue aims to summarize the current knowledge on the role of noncoding RNA in the process of various human diseases and disease models with animals and culture cells.

We look forward to your contributions.

Prof. Yasuhito Ishigaki
Guest Editor

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