Molecular Insights in Multiple Myeloma Pathogenesis

Dear Colleagues,

In the last few years, extensive preclinical research has led to impressive progress in the comprehension of the pathogenesis of multiple myeloma (MM). Indeed, the development of cell lines and the possibility to isolate primary malignant plasma cells and surrounding microenvironmental cells from the tumor bed have allowed investigators to apply “omics” assays to dissect the molecular pathways involved in the onset and progression of the disease. Furthermore, the peculiar natural history of MM, arising from asymptomatic stages, has prompted advanced studies of clonal dynamics and evolution which represent the basis of future investigations in other solid and hematological tumors.

The scope of this Special Issue is to collect original contributions from expert researchers in the field of MM molecular biology to outline the state-of-art of preclinical research and future perspectives in this area.

Prof. Dr. Marco Rossi
Guest Editor

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