Extracellular Vesicles in Health and Disease 2023

Dear Colleagues,

Extracellular vesicles (EVs) are heterogenous, phospholipid membrane-enclosed structures that are released by all eukaryotic and prokaryotic cells into the extracellular matrix under both physiological and pathological conditions. These nano-sized vesicles are 30–5000 nm in size and broadly classified into small and large EVs based on operational terms such as cell of origin, size, and biochemical composition. EVs contain a rich and diverse cargo of proteins, lipids, nucleic acids, and metabolites through which they mediate intercellular communication. The last few years have witnessed major development in EV research, including their role in numerous physiological processes such as immune regulation, tissue homeostasis, and development and pathological processes such as autoimmunity, neurodegenerative, cardiovascular, infectious, and neoplastic diseases. Apart from their role in disease pathology, EVs and their cargo have been proposed as reservoirs of biomarkers for various diseases. Furthermore, several studies have shed light on the significance of EVs as drug targets and delivery vehicles for treatment.

The aim of this Special Issue is to highlight the role of extracellular vesicles in various diseases, from disease pathology to diagnosis and treatment. We would like to invite experts to submit their unpublished original research and reviews with a comprehensive overview of EVs in health and diseases.

Dr. Pamali Fonseka
Dr. Han-soo Kim
Dr. Sai Vara Prasad Chitti
Guest Editors

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