Adrenergic Signaling in Health and Disease

Dear Colleagues,

Adrenoceptors are central mediators in the sympathetic nervous system, triggering the body’s ability to react to acute stress. Cathecolamines, released under stress conditions, bind to and activate α₁-adrenoceptors, α₂-adrenoceptors, and β-adrenoceptors to mediate cell-specific responses to adrenergic stimuli. The role of adrenergic system has been widely associated with the regulation of cardiovascular functions, with α- and β-adrenoceptors displaying opposite activity and representing crucial therapeutic targets for cardiovascular diseases. However, a relevant role of adrenoceptors is also increasingly emerging in several other tissues and organs such as the brain, retina, lungs, adipose tissue, kidney, urinary bladder, etc., in which altered adrenoceptor function is involved in clinically relevant disorders. In this respect, targeting specific α- and β-adrenoceptors subtypes has also become the subject of interest for the treatment of neurological, respiratory, metabolic, and urologic conditions. Novel insights into the α- and β-adrenoceptor signaling, and the relative ligands selectivity and specificity, represent the new frontier for the characterization of adrenergic system function from systemic to cell-specific levels in health and disease.

This Special Issue aims at providing a comprehensive overview of recent findings, broadening the knowledge on the adrenoceptor system and its potential role in physiology and disease. In particular, we invite you to provide original research articles investigating novel mechanistic insights into adrenoceptor function, as well as to summarize the current state of the art. Manuscripts providing translational value will be particularly welcome.

Prof. Paola Bagnoli
Guest Editor
Dr. Rosario Amato
co-Guest Editor

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