Prospects in GSK-3 Signaling: From Cellular Regulation to Disease Therapy

Dear Colleagues,

Research in the glycogen synthase kinase-3 (GSK-3) arena  is an inspiring example of scientific curiosity, twists in concepts, and unexpected surprises. GSK-3 participates in diverse biological processes and plays different roles in different contexts. Yet, it is a promising drug discovery target in treating multiple pathological conditions. Perhaps, the sophisticated mechanises in which GSK-3 is integrated into cellular networks is key in our understanding of the therapeutic benefits achieved with GSK-3 inhibition . Continuous research indeed uncovers new insights that are sometimes surprising of the molecular mechanisms underlying human diseases. The role of GSK-3 in the pathogenies of  diseases such as diabetes, psychiatric disorders and Alzheimer’s disease has been demonstrated, more connections describing GSK-3 with cellular targets and biological resposnes are uncovered in present studies.  Another ‘hot’ topic to be mentioned is the efforts in understanding the (potential) distinguished functions of GSK-3 isozymes, GSK-a and GSK-b, an issue that remains soemwhat elusive. In this Special Issue of Cells, I invite you to contribute, either in the form of original research articles, reviews, or shorter perspective articles on all aspects related to the theme of “Prospects in GSK-3 Signaling: From Cellular Regulation to Disease Therapy”. Expert articles describing mechanistic, functional, cellular, biochemical, and translational aspects of GSK-3 are highly welcome. Relevant topics include, but are not limited to:

• GSK-3
• Protein kinases
• Cell signaling
• Wnt signaling
• Neurodegenerative disorders
• Psychiatric disorders
• Development
• Sperm function
• Neuron plasticity
• Stem cell biology
• Translational medicine
• Drug discovery
• Drug design

Prof. Hagit Eldar-Finkelman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.