Cellular and Molecular Mechanisms in Eye Disease and Vision Disorders

A Special Issue of Cells (ISSN 2073-4409) belonging to the section "Cellular Pathology".

Deadline for manuscript submissions: 15 February 2027 | Viewed by 170

Editors


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Guest Editor
North Texas Eye Research Institute, University of North Texas Health, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
Interests: corneal disease; corneal cell biology; keratoconus; steroid hormones; neurodegeneration; molecular mechanisms

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Guest Editor
Department of Cell Biology and Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Interests: essential role of very long chain fatty acids in neuronal function in health and disease

Special Issue Information

Dear Colleagues,

Diseases which affect vision are a leading preventable cause of disability. Global prevalence of many vision disorders, such as glaucoma, cataracts, dry eye disease, and trauma-induced ocular injuries, are predicted to rise dramatically in the coming decades. Ocular research has been at the forefront of translational science, attempting to elucidate disease mechanisms and improve injury recovery. Indeed, the eye represents an ideal organ for investigating pharmaceutical targets, conducting biological fluid analysis, examining neurological function, and characterizing wound healing.

Despite the many recent advances in ocular research, numerous biomolecular mechanisms governing cellular function in the pathology of eye diseases and acute traumas remain poorly defined or understudied. Countless proteins, including growth factors, steroid hormones and inflammatory factors, become dysregulated in various ocular conditions. Beyond protein dysregulation, epigenetic modification of disease-associated genes mediated by microRNA and long non-coding RNAs also drives pathological progression in these eye ailments.

To advance these fields of research, we must further interrogate the cell signaling pathways which underline the function of all ocular tissues, from the outermost corneal epithelial cells to the deepest retinal ganglion cells. This Special Issue, “Cellular and Molecular Mechanisms in Eye Disease and Vision Disorders”, aims to advance this understanding by presenting a holistic selection of experimental and review articles describing an up-to-date status of ocular disease research.

Dr. Steve Mabry
Dr. Martin-Paul Agbaga
Guest Editors

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Keywords

  • cell signaling
  • eye disease
  • growth factor
  • hormones
  • inflammation
  • epigenetics

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Published Papers (1 paper)

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Review

50 pages, 4786 KB  
Review
Fibrotic Remodeling in Retinal Vascular Diseases: Cellular Origins, Molecular Mechanisms, and Therapeutic Perspectives
by Jia Yu Ning, Brian Wang, Miyuki Ishida Yamamoto and Kaori H. Yamada
Cells 2026, 15(19), 1772; https://doi.org/10.3390/cells15191772 - 29 Sep 2026
Abstract
Fibrosis is a major vision-threatening complication of neovascular retinal diseases, including neovascular age-related macular degeneration (nAMD) and proliferative diabetic retinopathy (PDR). Although vascular endothelial growth factor (VEGF) inhibition effectively suppresses vascular leakage and neovascularization, some patients still develop fibrosis and experience irreversible vision [...] Read more.
Fibrosis is a major vision-threatening complication of neovascular retinal diseases, including neovascular age-related macular degeneration (nAMD) and proliferative diabetic retinopathy (PDR). Although vascular endothelial growth factor (VEGF) inhibition effectively suppresses vascular leakage and neovascularization, some patients still develop fibrosis and experience irreversible vision loss. Recent studies have identified multiple interconnected signaling pathways that contribute to fibrotic progression, highlighting the potential need for combination or multitargeted therapeutic strategies. This review summarizes the cellular origins of myofibroblasts, the molecular mechanisms underlying fibrosis, and recent advances in antifibrotic therapies. We particularly highlight the angio-fibrotic switch, mesenchymal transition, cellular stress responses, extracellular matrix remodeling, mechanotransduction, and emerging therapeutic approaches for ocular fibrosis. Relevant preclinical and clinical studies were identified through searches of PubMed and clinical trial registries. Full article
(This article belongs to the Special Issue Cellular and Molecular Mechanisms in Eye Disease and Vision Disorders)
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