Special Issue "The Cell Biology of Coronavirus Infection"
Deadline for manuscript submissions: closed (15 January 2021).
Coronaviruses are enveloped positive strand RNA viruses that infect mammals and birds. They have the interesting property of assembling at intracellular membranes. About 20% of common colds in humans are caused by coronaviruses. More severe diseases, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), are caused by novel coronaviruses that emerged from animal sources. Another novel coronavirus related to SARS coronavirus (SARS CoV-2) emerged in December 2019 and has spread globally, with significant mortality and economic impact. Much progress has been made in understanding the infectious diseases caused by human coronaviruses since the emergence of SARS and MERS. The animal sources, epidemiology, and types of infections have been well documented. However, there are still no approved vaccines or antiviral therapeutics for any human coronavirus infection.
This lack of treatment is due in part to an incomplete understanding of the basic biology of this family of viruses. Of particular interest is the unknown advantage of intracellular assembly and mechanism of virus egress from infected cells. These characteristics are potential untapped avenues for novel antiviral strategies. In this Special Issue of Cells, coronavirus infection will be examined from a cell biological perspective. Potential topics include virus entry, formation of replication organelles, genome replication and production of viral mRNA, synthesis and targeting of viral proteins, and assembly and budding in the endoplasmic reticulum-Golgi intermediate compartment and virion egress. How cells respond to coronavirus infection is another important potential topic, including how interferon-stimulated genes impact infection.
Prof. Carolyn Machamer
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- membrane fusion
- intracellular assembly
- Golgi complex
- replication organelle
- host cell response