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Significance of NETs Formation in COVID-19

Department of Immunology, Medical University of Bialystok, J. Waszyngtona 15A, 15-269 Bialystok, Poland
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 151;
Received: 22 December 2020 / Revised: 7 January 2021 / Accepted: 12 January 2021 / Published: 14 January 2021
(This article belongs to the Special Issue The Cell Biology of Coronavirus Infection)
Severe contagious respiratory disease—COVID-19—caused by the SARS-CoV-2 coronavirus, can lead to fatal respiratory failure associated with an excessive inflammatory response. Infiltration and spread of SARS-CoV-2 are based on the interaction between the virus’ structural protein S and the cell’s receptor–angiotensin-converting enzyme 2 (ACE2), with the simultaneous involvement of human trans-membrane protease, serine 2 (TMPRSS2). Many scientific reports stress the importance of elevated recruitment and activity of neutrophils, which can form extracellular neutrophil traps (NETs) playing a significant role in the mechanism of combating pathogens, in the pathogenesis of COVID-19. Excessive generation of NETs during prolonged periods of inflammation predisposes for the occurrence of undesirable reactions including thromboembolic complications and damage to surrounding tissues and organs. Within the present manuscript, we draw attention to the impact of NET generation on the severe course of COVID-19 in patients with concurrent cardiovascular and metabolic diseases. Additionally, we indicate the necessity to explore not only the cellular but also the molecular bases of COVID-19 pathogenesis, which may aid the development of dedicated therapies meant to improve chances for the successful treatment of patients. We also present new directions of research into medications that display NETs formation regulatory properties as potential significant therapeutic strategies in the progress of COVID-19. View Full-Text
Keywords: COVID-19; SARS-CoV-1; NETs; neutrophils COVID-19; SARS-CoV-1; NETs; neutrophils
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MDPI and ACS Style

Janiuk, K.; Jabłońska, E.; Garley, M. Significance of NETs Formation in COVID-19. Cells 2021, 10, 151.

AMA Style

Janiuk K, Jabłońska E, Garley M. Significance of NETs Formation in COVID-19. Cells. 2021; 10(1):151.

Chicago/Turabian Style

Janiuk, Karolina; Jabłońska, Ewa; Garley, Marzena. 2021. "Significance of NETs Formation in COVID-19" Cells 10, no. 1: 151.

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