Next Article in Journal
Role of FOXO Transcription Factors in Cancer Metabolism and Angiogenesis
Next Article in Special Issue
Canonical and Noncanonical Autophagy as Potential Targets for COVID-19
Previous Article in Journal
Expression of Annexin A2 Promotes Cancer Progression in Estrogen Receptor Negative Breast Cancers
Previous Article in Special Issue
Host Gene Expression of Macrophages in Response to Feline Coronavirus Infection

Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection

Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biochemical Research Inc., Frederick, MD 21702, USA
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Author to whom correspondence should be addressed.
Cells 2020, 9(7), 1583;
Received: 1 June 2020 / Revised: 24 June 2020 / Accepted: 29 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue The Cell Biology of Coronavirus Infection)
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has resulted in >500,000 deaths worldwide, including >125,000 deaths in the U.S. since its emergence in late December 2019 and June 2020. Neither curative anti-viral drugs nor a protective vaccine is currently available for the treatment and prevention of COVID-19. Recently, new clinical syndromes associated with coagulopathy and vasculopathy have emerged as a cause of sudden death and other serious clinical manifestations in younger patients infected with SARS-CoV-2 infection. Angiotensin converting enzyme 2 (ACE2), the receptor for SARS-CoV-2 and other coronaviruses, is a transmembrane protein expressed by lung alveolar epithelial cells, enterocytes, and vascular endothelial cells, whose physiologic role is to induce the maturation of angiotensin I to generate angiotensin 1-7, a peptide hormone that controls vasoconstriction and blood pressure. In this review, we provide the general context of the molecular and cellular mechanisms of SARS-CoV-2 infection with a focus on endothelial cells, describe the vasculopathy and coagulopathy syndromes in patients with SARS-CoV-2, and outline current understanding of the underlying mechanistic aspects. View Full-Text
Keywords: COVID-19; SARS-CoV-2; ACE2; inflammatory cytokines; vasculopathy; vascular inflammation COVID-19; SARS-CoV-2; ACE2; inflammatory cytokines; vasculopathy; vascular inflammation
Show Figures

Graphical abstract

MDPI and ACS Style

Labò, N.; Ohnuki, H.; Tosato, G. Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection. Cells 2020, 9, 1583.

AMA Style

Labò N, Ohnuki H, Tosato G. Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection. Cells. 2020; 9(7):1583.

Chicago/Turabian Style

Labò, Nazzarena; Ohnuki, Hidetaka; Tosato, Giovanna. 2020. "Vasculopathy and Coagulopathy Associated with SARS-CoV-2 Infection" Cells 9, no. 7: 1583.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop