Novel Insights into the Role of Mitochondria in Neuropsychiatric and Neurodegenerative Disorders
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3952
Special Issue Editor
2. Faculty of Medicine, University of Coimbra, 3004-531 Coimbra, Portugal
Interests: neurons; mitochondria; calcium homeostasis; cell death; neurodegenerative disorders
Special Issue Information
Dear Colleagues,
Defects in mitochondrial function, dynamics and/or degradation have been largely described in defining the pathological mechanisms of several neurodegenerative disorders. Other evidence reports pre-symptomatic and early stage changes in different mitochondrial pathways, including redox modulation, mitochondrial quality control or the crosstalk with other organelles, as well as the transport of mitochondrial components between brain cells, revealing additional cellular mechanisms through which these “neuro-essential” organelles may be affected. Furthermore, many of these aspects have also been suggested to occur in different (neuro) psychiatric diseases, while various neurodegenerative diseases encompass early psychiatric symptoms. Neurodegenerative disorders include diverse clinical and pathological pathologies, characterized by progressive symptomatology, affecting selective brain areas and leading to cognitive decline, as well as the loss of memory and daily life functions. On the other hand, neuropsychiatric disorders encompass different mental diseases for which a fundamental neurobiological understanding has been suggested to explain behavioral development. Unfortunately, there is still no cure or neuroprotective treatments for these debilitating neuropsychiatric and neurodegenerative diseases, which supports the need for urgently identifying early diagnosis indicators and novel therapeutic targets and strategies for preventing or delaying the progression of these brain diseases.
This issue aims to cover the different aspects through which mitochondria may play a relevant role in both neuropsychiatric and neurodegenerative disorders.
Dr. Ana Cristina Rego
Guest Editor
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Keywords
- mitochondria
- redox changes
- autophagy
- therapies
- brain
- exossomes
- intercellular transport
- mitophagy
- mitochondrial quality control
- mitochondria-associated membrane
- psychiatric diseases
- synapses
- mitochondrial transport
- neurodegeneration
- synaptic dysfunction
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