Podocyte Pathophysiology

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 843

Special Issue Editor


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Guest Editor
Department of Medicine, Katz Family Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Interests: podocytes; glomerulus; innate immunity; STING; mitochondrial DNA; sphingolipids; lipids

Special Issue Information

Dear Colleagues,

While podocytes, highly specialized cells with a central role in filtration barrier maintenance, constitute a small cell population within the kidney, their significance in both normal glomerular physiology and the manifestation of proteinuric glomerulopathies cannot be underestimated. This is especially crucial considering that 90% of all chronic kidney disease cases are attributed to glomerular diseases. Decades of research have unveiled numerous aspects of podocyte biology in health and disease, positioning them at the forefront of preventive and therapeutic strategies for chronic progressive kidney diseases.

However, the complexity of podocyte biology, coupled with the development of innovative technical and methodological approaches, has brought new facets to light in characterizing the mechanisms governing podocyte development, metabolism, injury, and repair. These advancements enhance diagnostic techniques and therapeutics to treat glomerular diseases. Recent studies, such as the generation of kidney organoids from induced pluripotent stem cells and the exploration of podocyte mitochondria in glomerular cell crosstalk, have particularly piqued the field’s interest.

In this Special Issue, we eagerly invite basic research, clinical studies, and review articles focused on the investigation of the various aspects of podocyte pathology leading to glomerular diseases. This endeavor presents an excellent opportunity to not only update our current knowledge in the field but also to showcase diverse perspectives from institutions worldwide. 

Dr. Alla Mitrofanova
Guest Editor

Manuscript Submission Information

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Keywords

  • podocyte
  • podocytopathy
  • organoid
  • mitochondria
  • kidney therapy
  • actin cytoskeleton
  • integrity
  • glomerular basement membrane
  • extracellular matrix
  • intracellular trafficking
  • podocyte metabolism

Published Papers (1 paper)

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Review

17 pages, 2102 KiB  
Review
Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond
by Matthew Tolerico, Sandra Merscher and Alessia Fornoni
Cells 2024, 13(11), 890; https://doi.org/10.3390/cells13110890 - 22 May 2024
Viewed by 537
Abstract
Podocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid rafts, which are ordered membrane domains rich in [...] Read more.
Podocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid rafts, which are ordered membrane domains rich in cholesterol and sphingolipids, near the slit diaphragm highlights the importance of lipid metabolism in podocyte health. Emerging research shows the importance of sphingolipid metabolism to podocyte health through structural and signaling roles. Dysregulation in sphingolipid metabolism has been shown to cause podocyte injury and drive glomerular disease progression. In this review, we discuss the structure and metabolism of sphingolipids, as well as their role in proper podocyte function and how alterations in sphingolipid metabolism contributes to podocyte injury and drives glomerular disease progression. Full article
(This article belongs to the Special Issue Podocyte Pathophysiology)
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