Molecular Mechanism of Bone Disease

Dear Colleagues,

Skeletal pathologies afflict a considerable number of individuals worldwide, posing a significant socio-economic and healthcare challenge. Diseases impacting the skeletal system can arise from genetic mutations or result from metabolic alterations that compromise bone remodeling. Primary tumors (such as osteosarcoma) and bone metastases further contribute to the array of conditions affecting bone health. Understanding the molecular and cellular mechanisms leading to alterations in cells responsible for skeletal homeostasis, including osteoblasts and osteoclasts, is crucial. This knowledge not only aids in the identification of disease markers but also facilitates the discovery of molecular targets for the development of pharmaceuticals or treatments aimed at enhancing bone health. Moreover, lifestyle factors, such as nutrition and physical activity, play a role in modulating bone remodeling and counteracting degenerative skeletal pathologies.

Therefore, this Special Issue aims to discuss the latest insights into the molecular and cellular aspects associated with skeletal diseases, examining their roles both as outcomes and triggers. The exploration of molecular and cellular targets as prospective therapeutic avenues for averting or mitigating the advancement of these conditions will also be addressed.

We eagerly anticipate and welcome your valuable contributions.

Dr. Maria Teresa Valenti
Dr. Roberta Zerlotin
Guest Editors

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