Molecular Basis of Intestinal Epithelial Stem Cell Specification, Maintenance and Differentiation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 5137
Special Issue Editors
Interests: intestinal stem cells; embryonic intestinal stem cell progenitors; LGR receptors; GPCRs and metabolic control; regeneration of intestinal epithelium
Interests: intestinal stem cells; inflammatory bowel disease; intestinal cancer; signaling; chromatin
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
We welcome submissions of your latest research for a special issue: Molecular Basis of Intestinal Epithelial Stem Cell Specification, Maintenance and Differentiation. The small intestine has many vital functions, including absorption of nutrients, secretion of hormones and barrier in host defence against microorganisms. These functions of the small intestine depend on the correct specification and maintenance of differentiated epithelial cells. The continuous renewal of the epithelium is supported by Intestinal Stem Cells (ISCs). We know relatively well genetic factors that control self-renewal and differentiation of ISC population in homeostasis. Yet, we do not know whether each ISC responds equally to the differentiation stimuli. Moreover, the molecular events that control de-differentiation and proliferation of the intestinal epithelium upon injury are unclear. Recent studies demonstrated that reciprocal interactions between ISCs and immune cells are essential for tissue repair without excessive proliferation. There are strong links between the regeneration of intestinal epithelium, diet-derived nutrients, gut microbiota and their metabolites. However, the mechanisms underlying these correlations are not well established. This special issue focuses on the molecular mechanisms regulating intestinal stem cell functions in homeostasis and disease. We invite both original research articles and topical reviews.
Dr. Marie-Isabelle Garcia
Dr. Natalia Soshnikova
Guest Editors
Manuscript Submission Information
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Keywords
- intestinal stem cell
- microenvironment
- functional heterogeneity
- inflammation
- microbiota
- metabolism
- cancer
- signalling
- epigenetics
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