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Cells
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Inflammatory Pathways in Psychiatric Disorders
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Inflammatory Pathways in Psychiatric Disorders

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 30 September 2024 | Viewed by 1959

Special Issue Editor

Dr. Teresa Femenía

E-Mail Website
Guest Editor
Institute of Neurosciences, Spanish National Research Council (CSIC), Sant Joan d'Alacant, Spain
Interests: neuropharmacology; molecular immunobiology; behavior

Special Issue Information

Dear Colleagues,

Inflammatory pathways have emerged as a significant area of interest in understanding the pathophysiology of psychiatric disorders. Mounting evidence suggests that dysregulation of inflammatory processes plays a crucial role in the development and progression of conditions such as depression, anxiety disorders, and schizophrenia affecting both emotional and cognitive functions. Inflammatory markers, including cytokines, chemokines, and immune cells, have been found to be altered in individuals with psychiatric disorders, indicating the presence of an inflammatory state. In this special issue we aim to address a topic on the current understanding of the immune system and inflammatory pathways in psychiatric disorders, highlighting the potential mechanisms underlying their involvement and the implications for developing novel therapeutic approaches targeting inflammation in mental health conditions. We welcome original and review articles in animal and human studies.

Dr. Teresa Femenía
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • immune system
  • psychiatry
  • emotion
  • cognition

Published Papers (1 paper)

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Review

36 pages, 2323 KiB  
Review
Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets
by Bruna R. Kouba, Laura de Araujo Borba, Pedro Borges de Souza, Joana Gil-Mohapel and Ana Lúcia S. Rodrigues
Cells 2024, 13(5), 423; https://doi.org/10.3390/cells13050423 - 28 Feb 2024
Cited by 1 | Viewed by 1665
Abstract
The involvement of central and peripheral inflammation in the pathogenesis and prognosis of major depressive disorder (MDD) has been demonstrated. The increase of pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, IL-18, and TNF-α) in individuals with depression may elicit neuroinflammatory processes and peripheral inflammation, mechanisms [...] Read more.
The involvement of central and peripheral inflammation in the pathogenesis and prognosis of major depressive disorder (MDD) has been demonstrated. The increase of pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, IL-18, and TNF-α) in individuals with depression may elicit neuroinflammatory processes and peripheral inflammation, mechanisms that, in turn, can contribute to gut microbiota dysbiosis. Together, neuroinflammation and gut dysbiosis induce alterations in tryptophan metabolism, culminating in decreased serotonin synthesis, impairments in neuroplasticity-related mechanisms, and glutamate-mediated excitotoxicity. This review aims to highlight the inflammatory mechanisms (neuroinflammation, peripheral inflammation, and gut dysbiosis) involved in the pathophysiology of MDD and to explore novel anti-inflammatory therapeutic approaches for this psychiatric disturbance. Several lines of evidence have indicated that in addition to antidepressants, physical exercise, probiotics, and nutraceuticals (agmatine, ascorbic acid, and vitamin D) possess anti-inflammatory effects that may contribute to their antidepressant properties. Further studies are necessary to explore the therapeutic benefits of these alternative therapies for MDD. Full article
(This article belongs to the Special Issue Inflammatory Pathways in Psychiatric Disorders)
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