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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Functional Preservation and Personalized Surgery in Early-Stage Lung Cancer

edited by

Francesco Petrella

submission deadline 30 Apr 2027 | Submission Open

Keywords: early-stage lung cancer; non-small cell lung cancer (NSCLC); functional preservation; personalized surgery; precision surgery; parenchyma-sparing surgery; segmentectomy; sublobar resection; wedge resection; minimally invasive surgery; robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); pulmonary function; quality of life; patient-reported outcomes; frailty; surgical risk stratification; tumor biology; molecular profiling; biomarkers; radiomics; artificial intelligence; image-guided surgery; intraoperative navigation; fluorescence-guided surgery; surgical margins; lymph-node assessment; neoadjuvant therapy; adjuvant therapy; stereotactic body radiotherapy (SBRT); multidisciplinary treatment; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

The Role of Physical Activity in Cancer Prevention, Treatment and Rehabilitation

edited by

Iwona Malicka

and

Aleksandra Kowaluk

submission deadline 1 May 2027 | Viewed by 225 | Submission Open

Keywords: cancer; hematooncology; adults; children; physical activity; exercise; interventions; supportive care; prevention; recovery; quality of life

Gynecological Oncology and Robotic Surgery

edited by

Giuseppe Vizzielli

and

Giulia Pellecchia

submission deadline 10 May 2027 | Viewed by 366 | Submission Open

Keywords: gynecologic oncology; robotic-assisted surgery; minimally invasive surgery; artificial intelligence; surgical innovation; multidisciplinary care

(This special issue belongs to the Section Methods and Technologies Development)

The Clinical Trials and Management of Acute Myeloid Leukemia: 2nd Edition

edited by

Margaret T. Kasner

submission deadline 14 May 2027 | 2 articles | Viewed by 7627 | Submission Open

Keywords: acute myeloid leukemia; clinical trials; translational research; targeted therapies; novel agents

(This special issue belongs to the Section Clinical Research in Cancer)

Clinical Applications of Advanced MRI Technologies for Cancers

edited by

Nicolò Cardobi

submission deadline 15 May 2027 | 2 articles | Viewed by 2685 | Submission Open

Keywords: advanced MRI techniques; multiparametric imaging; quantitative biomarkers; artificial intelligence; treatment response assessment; precision oncology; radiomics; cancer diagnosis; functional imaging; molecular imaging

(This special issue belongs to the Section Methods and Technologies Development)

Overcoming Resistance in Hematologic Malignancies: From Mechanisms to Therapeutic Innovation

edited by Attaya Suvannasankha

submission deadline 15 May 2027 | Submission Open

Keywords: hematologic malignancies; leukemia; lymphoma; multiple myeloma; myelodysplastic syndromes; acute myeloid leukemia; chronic lymphocytic leukemia; targeted therapy; immunotherapy; cellular therapy; CAR-T; bispecific antibodies; antibody–drug conjugates; resistance mechanisms; therapeutic resistance; clonal evolution; tumor microenvironment; precision medicine; biomarkers; minimal residual disease; translational research; drug development; clinical trials; real-world evidence; implementation science; genomics; multi-omics; immune escape; personalized medicine; stem cell transplantation; hematologic oncology

Tumor Microenvironment of Gynecological Tumors

edited by

Zahid Pranjol

and

Dmitry Aleksandrovich Zinovkin

submission deadline 20 May 2027 | 4 articles | Viewed by 6204 | Submission Open

Keywords: tumor microenvironment; gynecological cancers; immunomodulation; cancer-associated fibroblasts; angiogenesis; cancer-like stem cells; extracellular matrix; immune evasion; cell signaling; therapeutics

(This special issue belongs to the Section Tumor Microenvironment)

Gynecologic Cancer: From Diagnosis to Treatment: 2nd Edition

edited by

Vito Andrea Capozzi

submission deadline 20 May 2027 | 2 articles | Viewed by 3185 | Submission Open

Keywords: endometrial cancer; cervical cancer; ovarian cancer; borderline ovarian tumor; diagnosis and treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Statistical and Machine Learning Methods for Cancer Research

edited by Anjishnu Banerjee

submission deadline 20 May 2027 | 2 articles | Viewed by 2402 | Submission Open

Keywords: statistical methods; machine learning; “Omics” research; adaptive clinical trials; drug development; personalized cancer therapies

(This special issue belongs to the Section Cancer Informatics and Big Data)

Surgical Management of Colorectal and Anal Cancers

edited by Gyung-mo Son

submission deadline 21 May 2027 | Viewed by 16 | Submission Open

Keywords: colorectal cancer; anal cancer; surgical treatment; management

(This special issue belongs to the Section Cancer Therapy)

Clinical Studies of Colorectal Cancer Surgery

edited by

Konstantinos Perivoliotis

and Ioannis Baloyiannis

submission deadline 25 May 2027 | Viewed by 317 | Submission Open

Keywords: colon; rectal; cancer; clinical; trials; evidence; open; laparoscopic; robotic; surgery

(This special issue belongs to the Section Clinical Research in Cancer)

Novel Minimally Invasive Surgery for Urological Oncology: Techniques and Outcomes

edited by Grivas Nikolaos and Filippos Nikitakis

submission deadline 28 May 2027 | Viewed by 62 | Submission Open

Keywords: robot-assisted radical prostatectomy; laparoscopic partial nephrectomy; minimally invasive cystectomy; urinary continence recovery; oncological outcomes; Retzius-sparing surgery; intraoperative image guidance; surgical innovation in uro-oncology

Integrating Molecular and Conventional Diagnostics in Thyroid Nodule Management: Implications for Cancer Diagnosis and Treatment

edited by

Kennichi Kakudo

and Yanhua Bai

submission deadline 30 May 2027 | 3 articles | Viewed by 2174 | Submission Open

Keywords: thyroid carcinoma; low-risk neoplasm; indeterminate thyroid nodule; molecular testing; ultrasound; FNA cytology; integrated risk stratification; multidisciplinary team discussion; active surveillance; conservative management

Current Status of Neuroendocrine Tumors with a Special Focus on Diagnosis and Novel Treatments—3rd Edition

edited by

Dan Granberg

submission deadline 30 May 2027 | 2 articles | Viewed by 1401 | Submission Open

Keywords: neuroendocrine tumors; somatostatin analogues; PRRT; chemotherapy; 68Gallium-DOTATOC; PET; CT; targeted therapies; mTOR; inhibitors; angiogenesis

(This special issue belongs to the Section Cancer Therapy)

Research Progress in Artificial Intelligence of Radiation Oncology: Diagnosis and Therapy

edited by

Abadh Kishore Chaurasia

submission deadline 30 May 2027 | Viewed by 269 | Submission Open

Keywords: artificial intelligence; radiation oncology; digital pathology; biomarker prediction; outcome prediction; vision transformer; foundation model

(This special issue belongs to the Section Methods and Technologies Development)

Drug Resistance Mechanisms and Tumor Microenvironment in Upper Gastrointestinal Cancers

edited by

Zheng Chen

and Heng Lu

submission deadline 31 May 2027 | 2 articles | Viewed by 2686 | Submission Open

Keywords: drug resistance; tumor microenvironment; gastric cancer; esophageal cancer; immunotherapy; targeted therapy; biomarkers; precision medicine

(This special issue belongs to the Section Tumor Microenvironment)

Cancer After Kidney Transplant

edited by Sławomir Lizakowski

submission deadline 31 May 2027 | 2 articles | Viewed by 2165 | Submission Open

Keywords: immunosuppression; virus-associated cancer; skin cancer; graft survival; kidney transplantation; post-transplantation lymphoproliferative disorder

(This special issue belongs to the Section Transplant Oncology)

Psychological Factors and Cancer Survivorship

edited by

Deidre B. Pereira

and Ashley P. Ghiaseddin

submission deadline 31 May 2027 | 3 articles | Viewed by 1508 | Submission Open

Keywords: psycho-oncology; distress; distress management; biobehavior markers and mechanisms; quality of life outcomes; treatment outcomes; survival outcomes

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Cancer Drug Resistance: Mechanisms and Overcoming Strategies

edited by

Jessica M. Konen

submission deadline 31 May 2027 | 2 articles | Viewed by 1446 | Submission Open

Keywords: intrinsic resistance; acquired resistance; targeted therapy resistance; combination treatment strategies; immunotherapy resistance; tumor heterogeneity

(This special issue belongs to the Section Clinical Research in Cancer)

Strategies and Techniques in Diagnosing, Treating and Surveying Sarcoma

edited by H. Thomas Temple

submission deadline 31 May 2027 | 2 articles | Viewed by 1327 | Submission Open

Keywords: sarcoma; diagnosis; therapy; treatment; surgery; molecular; radiomics

Liver Transplantation Oncology: Innovations, Multidisciplinary Management, and Evolving Clinical Strategies

edited by

Sami Akbulut

and

Tevfik Tolga Şahin

submission deadline 31 May 2027 | Viewed by 384 | Submission Open

Keywords: liver transplantation; transplant oncology; hepatobiliary oncology; hepatocellular carcinoma; cholangiocarcinoma; gallbladder cancer; primary liver cancer; secondary liver malignancies; colorectal liver metastases; neuroendocrine liver metastases; surgical oncology; locoregional therapy; systemic therapy; bridging therapy; downstaging; tumor recurrence; cancer surveillance; precision oncology; cancer biomarkers; artificial intelligence; clinical prediction models; real-world evidence; comparative effectiveness research; multidisciplinary cancer care

(This special issue belongs to the Section Clinical Research in Cancer)

Metabolomics Approaches in Cancer Diagnosis

edited by

Raj Kumar Sharma

submission deadline 31 May 2027 | Viewed by 314 | Submission Open

Keywords: metabolomics; metabolites; NMR metabolomics; mass spectrometry in metabolomics; cancer biomarkers; metabolomics methods

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Radiation Therapy for Pediatric Cancers: Precision Techniques, Late Effects, and Survivorship Strategies

edited by

John T. Lucas, Jr.

and

Chincheng Chen

submission deadline 31 May 2027 | Viewed by 302 | Submission Open

Keywords: pediatric radiation therapy; pediatric proton therapy; adaptive radiation therapy; advances in treatment planning and delivery; boron neutron capture therapy; molecularly targeted radiation therapy; late effects and survivorship; neurocognitive preservation; radiation-induced secondary malignancies; radiobiology of developing tissues; intellectual changes; cognitive outcomes

(This special issue belongs to the Section Pediatric Oncology)

Transcription Factors and Their Involvement in Carcinogenesis

edited by

Richard Morgan

submission deadline 31 May 2027 | Viewed by 275 | Submission Open

Keywords: transcription factors; transcription; transcriptome biomarkers; personalized medicine

(This special issue belongs to the Section Molecular Cancer Biology)

Perspectives in Surgical Treatments of Gastrointestinal Cancer

edited by Jayesh Sagar

submission deadline 31 May 2027 | Viewed by 231 | Submission Open

Keywords: artificial intelligence; robotic surgery; GI surgery; colorectal cancer

(This special issue belongs to the Section Methods and Technologies Development)

The Next Decade of Proton Therapy: Emerging Technologies, Clinical Translation and Grand Challenges

edited by

Xiao Wang

and

Zhiyan Xiao

submission deadline 31 May 2027 | Viewed by 156 | Submission Open

Keywords: image-guided proton therapy; emerging technologies; adaptive proton therapy; proton arc therapy; FLASH proton therapy; artificial intelligence; LET and RBE; biological optimization and robust optimization; precision radiation oncology; grand challenges

(This special issue belongs to the Section Cancer Therapy)

Technology for Tumor Biomarker Detection

edited by Gourav Kumar

submission deadline 31 May 2027 | Viewed by 152 | Submission Open

Keywords: early cancer detection; molecular imaging probes; liquid biopsy assays; advanced biosensors; microfluidic devices

(This special issue belongs to the Section Methods and Technologies Development)

Artificial Intelligence in Cancer Screening and Diagnostic Imaging

edited by

Lin-Ching Chang

Huiru Zheng

and

Zhaohui Liang

submission deadline 31 May 2027 | Viewed by 137 | Submission Open

Keywords: artificial intelligence; cancer screening; cancer diagnosis; medical image analysis; deep learning; large language models; multimodal and vision-language models; radiomics; computer-aided detection and diagnosis; explainable AI; precision oncology; AI-guided therapy planning

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The New Era of ctDNA-Guided Precision Oncology: Escalation, De-Escalation, and Treatment Adaptation Across Solid and Hematologic Malignancies

edited by

Jad Chahoud

submission deadline 31 May 2027 | Viewed by 124 | Submission Open

Keywords: ctDNA; circulating tumor DNA; minimal residual disease; molecular residual disease; precision oncology; treatment escalation; treatment de-escalation; adaptive therapy; liquid biopsy; real-world evidence

(This special issue belongs to the Section Cancer Therapy)

Novel Surgical Treatment Approaches in Advanced Gastrointestinal Neoplasms, 2nd Edition

edited by Agostino Maria De Rose and Francesco Santullo

submission deadline 31 May 2027 | Viewed by 64 | Submission Open

Keywords: advanced gastrointestinal neoplasms; colon cancer; cytoreductive surgery; gastric cancer; liver metastases; peritoneal metastases; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy); pancreatic cancer

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Precision Oncology: From Biomarkers and Early Detection to Prevention and Therapy

edited by

Nelson Yee

submission deadline 31 May 2027 | Viewed by 45 | Submission Open

Keywords: artificial intelligence; biomarker; cancer screening; clinical trials; digital twins; early detection; liquid biopsy; machine learning; multi-omics; precision oncology; targeted therapies; molecular targets; screening

Photodynamic Therapy (PDT) and Proton Therapy (PT) of Cancer

edited by

Kave Moloudi

submission deadline 31 May 2027 | Viewed by 17 | Submission Open

Keywords: photo-dynamic therapy; photosensitizers; particle therapy; cancer resistance; immune response

(This special issue belongs to the Section Cancer Therapy)

Obesity and Metabolic Syndrome in Cancers

edited by Tseng Chin-Hsiao

submission deadline 31 May 2027 | Viewed by 16 | Submission Open

Keywords: obesity; metabolic syndrom; cancer; diabetes mellitus; insulin resistance; antidiabetic drugs; metformin

Advances in Flow Cytometry for Hematological Malignancies

edited by Yijie Liu

submission deadline 31 May 2027 | Viewed by 1 | Submission Open

Keywords: flow cytometry; MRD; leukemia; lymphoma

(This special issue belongs to the Section Methods and Technologies Development)

Molecularly Targeted Therapies for Lung Cancer

edited by Shuhang Wang

submission deadline 31 May 2027 | Submission Open

Keywords: lung cancer; non-small-cell lung cancer (NSCLC); molecular targeted therapy; precision oncology; oncogenic drivers; tyrosine kinase inhibitors; drug resistance; antibody-drug conjugates; liquid biopsy; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Advances in Exercise Oncology: From Clinical Trials to Cancer Survivorship Care

edited by Linda M. O’Neill and Gráinne Sheill

submission deadline 31 May 2027 | Submission Open

Keywords: exercise oncology; prehabilitation; rehabilitation; implementation; physical activity

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Evidence-Based Care for Managing Oncologic Emergencies in Patients with Cancer

edited by

Aiham Qdaisat

and

Sai-Ching Jim Yeung

submission deadline 1 Jun 2027 | 1 articles | Viewed by 1650 | Submission Open

Keywords: oncologic emergencies; cancer; urgent; infections; adverse events; thrombosis; febrile neutropenia; pain; spinal cord compression; goals of care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Intratumoral and Locoregional Drug Delivery for Malignant Brain Tumors

edited by

Tomasz Tykocki

submission deadline 10 Jun 2027 | Viewed by 98 | Submission Open

Keywords: glioblastoma; diffuse midline glioma; blood–brain barrier; convection-enhanced delivery; locoregional therapy; intratumoral drug delivery; CAR-T cell therapy; oncolytic virotherapy; focused ultrasound; nanoparticle drug delivery

(This special issue belongs to the Section Cancer Drug Development)

Tumor Evolution and Microenvironmental Dynamics in Advanced Prostate Cancer: From Biology to Precision Medicine

edited by

Theocharis Panaretakis

, Paul G. Corn and Christopher J. Logothetis

submission deadline 11 Jun 2027 | Submission Open

Keywords: prostate cancer; tumor evolution; tumor microenvironment; therapy resistance; androgen receptor; lineage plasticity; neuroendocrine prostate cancer; single-cell sequencing; liquid biopsy; precision oncology

(This special issue belongs to the Section Tumor Microenvironment)

Pathological Features and Treatment Strategies of Head and Neck Cancer

edited by

Davide Mattavelli

and

Boštjan Lanišnik

submission deadline 15 Jun 2027 | 1 articles | Viewed by 876 | Submission Open

Keywords: head and neck cancer (HNC); pathological features; treatment strategies; human papillomavirus (HPV); molecular profile; multimodal therapy; immune checkpoint inhibitors; prognostic markers

(This special issue belongs to the Section Clinical Research in Cancer)

Nanotechnology in Radiation Oncology

edited by

Kalliopi Platoni

submission deadline 15 Jun 2027 | 1 articles | Viewed by 388 | Submission Open

Keywords: external radiation therapy; brachytherapy; hyperthermia; cancer; nanotechnology; radiosensitizers; nanoparticles

Integrative Imaging–Genomic Modeling and AI for Precision Oncology

edited by

Golrokh Mirzaei

submission deadline 15 Jun 2027 | Viewed by 342 | Submission Open

Keywords: imaging–genomic modeling; precision oncology; machine learning; cancer imaging; digital pathology; radiogenomics; biomarker discovery; multimodal data integration

(This special issue belongs to the Section Methods and Technologies Development)

Epigenomics and Transcriptomics in Cancer Progression and Therapy

edited by

Ravindra Kumar

and Rajrani Ruhel

submission deadline 15 Jun 2027 | Viewed by 33 | Submission Open

Keywords: bioinformatics; computational biology; data analysis; cancer; transcriptomics; epigenomics

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular and Cellular Pathogenesis of Lung Cancer

edited by

Lamjed Mansour

submission deadline 20 Jun 2027 | Viewed by 80 | Submission Open

Keywords: lung cancer; molecular pathogenesis; cellular mechanisms; tumor microenvironment; oncogenic signaling; immune evasion; therapeutic resistance; biomarkers; precision oncology

(This special issue belongs to the Section Cancer Pathophysiology)

Multimodal Supportive Care in Oncology: Integrating Nutritional and Physical Interventions into the Treatment Pathway

edited by

Fabio Monzani

Giuseppe Pasqualetti

and Loupakis Fotios

submission deadline 25 Jun 2027 | Submission Open

Keywords: supportive care in oncology; multimodal intervention; cancer cachexia; malnutrition; oral nutritional supplements; exercise oncology; prehabilitation; body composition; treatment tolerability; quality of life

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

The Emerging Role of Multiplexed Imaging for Cancer Diagnosis and Therapy (2nd Edition)

edited by

Li Liu

and

Yicheng Ni

submission deadline 30 Jun 2027 | 4 articles | Viewed by 8462 | Submission Open

Keywords: multiplexed imaging; cancer diagnosis; molecular imaging; novel contrast agents; targeted radionuclide tracers theragnostics; personalized cancer therapy; therapeutic monitoring; imaging biomarkers; clinical translation

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Biomarkers of Urological Cancers

edited by

Aristotelis Bamias

Michalis Liontos

and Zisis Kratiras

submission deadline 30 Jun 2027 | 6 articles | Viewed by 6063 | Submission Open

Keywords: biomarkers; urothelial cancer; prostate cancer; renal cancer; checkpoint inhibitors; PD-L1; KIM-1; FGFR3; BRCA; HRD

(This special issue belongs to the Section Cancer Biomarkers)

Exercise and Cancer Treatment: The Clinical Application of Exercise Oncology

edited by

Helena Batatinha

and Geovana Leite

submission deadline 30 Jun 2027 | 4 articles | Viewed by 5719 | Submission Open

Keywords: exercise oncology; cancer therapy; immunotherapy; patient outcomes

(This special issue belongs to the Section Clinical Research in Cancer)

Advances in Dermato-Oncology

edited by Carmen Cantisani

submission deadline 30 Jun 2027 | 4 articles | Viewed by 3697 | Submission Open

Keywords: melanoma; line-field confocal optical coherence tomography (LC-OCT); confocal microscopy; dermoscopy; non-melanoma skin cancers; treatment

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Neurofibromatosis Type 1 (NF1) Related Tumors (2nd Edition)

edited by

Daochun Sun

and

Sameer Farouk Sait

submission deadline 30 Jun 2027 | 1 articles | Viewed by 2192 | Submission Open

Keywords: NF1; tumorigenesis; cancer stem cells; targeted therapy; tumor microenvironment; epigenetics; case report; metastasis; clinical trials

(This special issue belongs to the Section Tumor Microenvironment)

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