New Molecular Targets and Emerging Approaches to Target Cancer Stem Cells

Dear Colleagues，

The so-called cancer stem cells (CSCs) were previously identified and characterized in several types of cancer. Although present in small numbers, CSCs have been shown to have a high impact on the renewal of the tumors, contributing to progression, metastasis and resistance to therapies. Therefore, these cells constitute a promising target for therapy, to be used alone or in combination with conventional treatment options.

This Special Issue aims to highlight the most recent advances in the field of CSCs, focusing on their malignant characteristics and weaknesses, and potential novel approaches to target them. Potential topics include, but are not limited to, the following:

• Molecular players and signaling pathways supporting CSC self-renewal, survival, cell cycle progression, invasiveness and metastases;
• Metabolic alterations in CSCs;
• Determinants of cancer cell plasticity;
• Mechanisms supporting immune surveillance avoidance;
• Mechanisms involved in treatment resistance and cancer relapse;
• Novel agents to target CSCs and clinical trials;
• Differentiation therapies.

Dr. José Braganca
Dr. Mónica Fernandes
Guest Editors

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