Special Issue "PTEN: A Multifaceted Tumor Suppressor"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (15 June 2019) | Viewed by 35550
Interests: PTEN; biomarkers; targeted therapy; molecular biology
Interests: methodology of clinical trials; biomarker clinical validation; meta-analyses
PTEN is the main negative regulator of PI3K pathway. PTEN levels and/or function can be regulated through multiple mechanisms (e.g., epigenetic silencing, post-translational modifications, etc.), and its protein and lipid phosphatase activity is involved in different cell functions, such as survival, growth, DNA repair, and protein synthesis. Its function is determined, at least in part, by its subcellular localization and a longer PTEN variant, named PTEN long, which may be implicated in paracrine cell-cell communication.
Germline loss of PTEN expression/function results in hereditary cancer predisposition syndromes, clinically referred to as PTEN hamartoma syndromes (PHTS) or PTENopaties, which carry a high lifetime risk of developing either benign or malignant growth in different target organs. Moreover, somatic PTEN aberrations are frequently observed in a wide spectrum of sporadic cancers, such as glioblastoma multiforme, malignant melanoma, endometrial, prostate, breast, colorectal, and lung cancers. Indeed, PTEN is a haploinsufficient tumor suppressor, and even subtle reductions in its active levels dictate cancer susceptibility in a dose-dependent manner.
In this Special Issue, we will focus on the mechanisms regulating PTEN expression and function, as well as on its functional role in PTENopaties and cancer, highlighting its prognostic/predictive potential and examining possible strategies to target PTEN-deficient tumors.
Dr. Ludovica Ciuffreda
Dr. Emilio Bria
Dr. Robert Pilarski
Manuscript Submission Information
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- hereditary syndrome
- hereditary cancer
- biomarker clinical validation