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PTEN and Gynecological Cancers

Gynecologic Oncology, Dipartimento per le Scienze della Salute della Donna, Fondazione Policlinico Universitario A. Gemelli IRCCS, del Bambino e di Sanità Pubblica, 00168 Roma, Italy
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Cancers 2019, 11(10), 1458;
Received: 13 August 2019 / Revised: 16 September 2019 / Accepted: 24 September 2019 / Published: 28 September 2019
(This article belongs to the Special Issue PTEN: A Multifaceted Tumor Suppressor)
PTEN is a tumour suppressor gene, and its loss of function is frequently observed in both heritable and sporadic cancers. It is involved in a great variety of biological processes, including maintenance of genomic stability, cell survival, migration, proliferation and metabolism. A better understanding of PTEN activity and regulation has therefore emerged as a subject of primary interest in cancer research. Gynaecological cancers are variously interested by PTEN deregulation and many perspective in terms of additional prognostic information and new therapeutic approaches can be explored. Here, we present the most significant findings on PTEN in gynaecological cancers (ovarian, endometrial, cervical, vulvar and uterine cancer) focusing on PTEN alterations incidence, biological role and clinical implications. View Full-Text
Keywords: PTEN; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; uterine cancer PTEN; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; uterine cancer
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Nero, C.; Ciccarone, F.; Pietragalla, A.; Scambia, G. PTEN and Gynecological Cancers. Cancers 2019, 11, 1458.

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