Next Article in Journal
P120 Catenin Isoforms Differentially Associate with Breast Cancer Invasion and Metastasis
Next Article in Special Issue
Revising PTEN in the Era of Immunotherapy: New Perspectives for an Old Story
Previous Article in Journal
c-Myc Acts as a Competing Endogenous RNA to Sponge miR-34a, in the Upregulation of CD44, in Urothelial Carcinoma
Previous Article in Special Issue
Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cancers
Volume 11
Issue 10
10.3390/cancers11101458
cancers-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

PTEN and Gynecological Cancers

by
Camilla Nero
*,
Francesca Ciccarone
,
Antonella Pietragalla
and
Giovanni Scambia
Gynecologic Oncology, Dipartimento per le Scienze della Salute della Donna, Fondazione Policlinico Universitario A. Gemelli IRCCS, del Bambino e di Sanità Pubblica, 00168 Roma, Italy
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(10), 1458; https://doi.org/10.3390/cancers11101458
Submission received: 13 August 2019 / Revised: 16 September 2019 / Accepted: 24 September 2019 / Published: 28 September 2019
(This article belongs to the Special Issue PTEN: A Multifaceted Tumor Suppressor)
Browse Figures
Versions Notes

Abstract

PTEN is a tumour suppressor gene, and its loss of function is frequently observed in both heritable and sporadic cancers. It is involved in a great variety of biological processes, including maintenance of genomic stability, cell survival, migration, proliferation and metabolism. A better understanding of PTEN activity and regulation has therefore emerged as a subject of primary interest in cancer research. Gynaecological cancers are variously interested by PTEN deregulation and many perspective in terms of additional prognostic information and new therapeutic approaches can be explored. Here, we present the most significant findings on PTEN in gynaecological cancers (ovarian, endometrial, cervical, vulvar and uterine cancer) focusing on PTEN alterations incidence, biological role and clinical implications.
Keywords: PTEN; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; uterine cancer PTEN; ovarian cancer; endometrial cancer; cervical cancer; vulvar cancer; uterine cancer

Share and Cite

MDPI and ACS Style

Nero, C.; Ciccarone, F.; Pietragalla, A.; Scambia, G. PTEN and Gynecological Cancers. Cancers 2019, 11, 1458. https://doi.org/10.3390/cancers11101458

AMA Style

Nero C, Ciccarone F, Pietragalla A, Scambia G. PTEN and Gynecological Cancers. Cancers. 2019; 11(10):1458. https://doi.org/10.3390/cancers11101458

Chicago/Turabian Style

Nero, Camilla, Francesca Ciccarone, Antonella Pietragalla, and Giovanni Scambia. 2019. "PTEN and Gynecological Cancers" Cancers 11, no. 10: 1458. https://doi.org/10.3390/cancers11101458

APA Style

Nero, C., Ciccarone, F., Pietragalla, A., & Scambia, G. (2019). PTEN and Gynecological Cancers. Cancers, 11(10), 1458. https://doi.org/10.3390/cancers11101458

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop