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Open AccessReview

Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives

1
Department of Medicine, University of Verona, 37126 Verona, Italy
2
Division of Gynecologic Oncology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy
3
Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy
4
Division of Medical Oncology 2, Istituto Oncologico Veneto IRCCS, 35128 Padova, Italy
*
Author to whom correspondence should be addressed.
L.C. and F.M. share the first co-authorship.
Cancers 2019, 11(9), 1401; https://doi.org/10.3390/cancers11091401
Received: 3 August 2019 / Revised: 12 September 2019 / Accepted: 15 September 2019 / Published: 19 September 2019
(This article belongs to the Special Issue PTEN: A Multifaceted Tumor Suppressor)
The characterization of tumor biology and consequently the identification of prognostic and predictive biomarkers represent key issues for the translational research in breast cancer (BC). Phosphatase and tensin homolog deleted on chromosome ten (PTEN), the negative regulator of the proto-oncogenic phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway, constitutes one of the most intriguing tumor suppressor genes involved in a series of biological processes, such as cell growth and survival, cellular migration and genomic stability. Loss of PTEN activity, due to protein, genetic or epigenetic alterations, was reported in up to almost half of BC cases. Recently, besides the role of PTEN in the pathogenesis of BC, investigated for over 20 years after the PTEN discovery, several retrospective and prospective translational studies, in the early and advanced setting, reported controversial results regarding the association between PTEN functional status and both clinical outcome and response to various BC treatments. This review explores the pre-clinical and clinical role of PTEN in BC with regard to the potential association of PTEN with prognosis and treatment response or resistance, underlying the complexity of the interpretation of available results and suggesting potential future perspectives. View Full-Text
Keywords: PTEN; breast cancer; prognosis; predictive role; treatment response; survival PTEN; breast cancer; prognosis; predictive role; treatment response; survival
MDPI and ACS Style

Carbognin, L.; Miglietta, F.; Paris, I.; Dieci, M.V. Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives. Cancers 2019, 11, 1401. https://doi.org/10.3390/cancers11091401

AMA Style

Carbognin L, Miglietta F, Paris I, Dieci MV. Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives. Cancers. 2019; 11(9):1401. https://doi.org/10.3390/cancers11091401

Chicago/Turabian Style

Carbognin, Luisa; Miglietta, Federica; Paris, Ida; Dieci, Maria V. 2019. "Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives" Cancers 11, no. 9: 1401. https://doi.org/10.3390/cancers11091401

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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