Special Issue "Small GTPases in Cancer"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 January 2016).
The Ras superfamily of GTPases comprises several subfamilies of small GTP-binding proteins whose functions have been implicated in the control of cell proliferation, differentiation, protein transport, cytoskeleton organization, etc. Ras proteins are key components of the signal transduction pathways triggered by a number of different extracellular signals, such as mitogens. KRAS and NRAS mutations have been implicated in quite a number of human cancers. Deregulation of many upstream molecules also triggers deregulation of the activity of Ras proteins, leading to the development of cancer. Rho GTPases are involved in multiple cellular processes that could also affect cancer progression, namely cytoskeletal organization, cell cycle progression, the regulation of transcription, and protein trafficking. Some Rho GTPases have been shown to have oncogenic activity and/or can promote cancer cell invasion. Con the other hand, as other subfamily members, appear to act as tumor suppressors and are deleted, mutated or deregulated in some cancers. Rab subfamily members are mostly involved in vesicular trafficking and it seems that deregulation of some of them is correlated with a worsened outcome in human cancers. In this Special Issue of Cancers, "Small GTPases in Cancer", experts are invited to contribute original research papers or review articles that will provide further insights on the various functions of small GTPases in cancers, their role in cancer biology, as well as a possibility to use them as drug targets and biomarkers.
Dr. Jonas Cicenas
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- small GTPases
- Ras family
- KRAS mutations
- NRAS mutations