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A Review of the Role of Wnt in Cancer Immunomodulation
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Wnt Signaling in Cancer Metabolism and Immunity

1,2,3,4,†, 5,†, 1,2,3,4,6,7,* and 5,*
1
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
2
Ottawa Institute of Systems Biology, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
3
China-Canada Centre of Research for Digestive Diseases, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
4
Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai 200032, China
5
Institute of Chinese Traditional Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai 200032, China
6
Ottawa Hospital Research Institute, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada
7
Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada
*
Authors to whom correspondence should be addressed.
These authors contribute equally to this work.
Cancers 2019, 11(7), 904; https://doi.org/10.3390/cancers11070904
Received: 31 May 2019 / Revised: 22 June 2019 / Accepted: 26 June 2019 / Published: 28 June 2019
(This article belongs to the Special Issue Targeting Wnt Signaling in Cancer)
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PDF [1351 KB, uploaded 28 June 2019]
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Abstract

The Wingless (Wnt)/β-catenin pathway has long been associated with tumorigenesis, tumor plasticity, and tumor-initiating cells called cancer stem cells (CSCs). Wnt signaling has recently been implicated in the metabolic reprogramming of cancer cells. Aberrant Wnt signaling is considered to be a driver of metabolic alterations of glycolysis, glutaminolysis, and lipogenesis, processes essential to the survival of bulk and CSC populations. Over the past decade, the Wnt pathway has also been shown to regulate the tumor microenvironment (TME) and anti-cancer immunity. Wnt ligands released by tumor cells in the TME facilitate the immune evasion of cancer cells and hamper immunotherapy. In this review, we illustrate the role of the canonical Wnt/β-catenin pathway in cancer metabolism and immunity to explore the potential therapeutic approach of targeting Wnt signaling from a metabolic and immunological perspective. View Full-Text
Keywords: Wnt; cancer; glycolysis; glutaminolysis; lipogenesis; metabolic negative feedback; dendritic cells; T cells; cancer immunotherapy Wnt; cancer; glycolysis; glutaminolysis; lipogenesis; metabolic negative feedback; dendritic cells; T cells; cancer immunotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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El-Sahli, S.; Xie, Y.; Wang, L.; Liu, S. Wnt Signaling in Cancer Metabolism and Immunity. Cancers 2019, 11, 904.

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