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A Role for the WNT Co-Receptor LRP6 in Pathogenesis and Therapy of Epithelial Cancers
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Wnt Signaling Pathways in Keratinocyte Carcinomas

de Duve Institute, Université catholique de Louvain, Brussels 1200, Belgium
*
Author to whom correspondence should be addressed.
Authors contributed equally.
Cancers 2019, 11(9), 1216; https://doi.org/10.3390/cancers11091216
Received: 20 July 2019 / Revised: 17 August 2019 / Accepted: 19 August 2019 / Published: 21 August 2019
(This article belongs to the Special Issue Targeting Wnt Signaling in Cancer)
The skin functions as a barrier between the organism and the surrounding environment. Direct exposure to external stimuli and the accumulation of genetic mutations may lead to abnormal cell growth, irreversible tissue damage and potentially favor skin malignancy. Skin homeostasis is coordinated by an intricate signaling network, and its dysregulation has been implicated in the development of skin cancers. Wnt signaling is one such regulatory pathway orchestrating skin development, homeostasis, and stem cell activation. Aberrant regulation of Wnt signaling cascades not only gives rise to tumor initiation, progression and invasion, but also maintains cancer stem cells which contribute to tumor recurrence. In this review, we summarize recent studies highlighting functional evidence of Wnt-related oncology in keratinocyte carcinomas, as well as discussing preclinical and clinical approaches that target oncogenic Wnt signaling to treat cancers. Our review provides valuable insight into the significance of Wnt signaling for future interventions against keratinocyte carcinomas. View Full-Text
Keywords: Wnt signaling; non-melanoma skin cancer; basal cell carcinoma; squamous cell carcinoma Wnt signaling; non-melanoma skin cancer; basal cell carcinoma; squamous cell carcinoma
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MDPI and ACS Style

Lang, C.M.R.; Chan, C.K.; Veltri, A.; Lien, W.-H. Wnt Signaling Pathways in Keratinocyte Carcinomas. Cancers 2019, 11, 1216.

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