PARP Enzymes, ADP-Ribose and NAD+ Metabolism in Cancer

Dear Colleagues,

We are arranging a Special Issue in the journal Cancers (Impact Factor: 6.639). This Special Issue of Cancers will consist of research and review articles on “PARP Enzymes, ADP-ribose, and NAD+ Metabolism in Cancer”. It will focus on selected papers from the FEBS Advanced Lecture Course conference on “PARP2021: Research on the Family of Poly(ADP-ribose) Polymerases” (https://parp2021.febsevents.org/), that takes place in Barcelona (Spain) on 7–10 September 2021, but all manuscripts relevant to the topic are welcome.

PARPs were discovered in the 1960s, with their role in DNA repair and maintenance of DNA structure first being established. The development of PARP inhibitors allowed the identification of a plethora of other PARP-mediated biological processes ranging from metabolism, through viral biology to aging. Establishing knockout mouse strains further widened the scope of our understanding of PARP biology. Novel mass-spectrometry-based methods can establish the PARylome in biological models and can be of help to identify binding partners of PARPs or proteins that bind PAR itself. These findings led to the development of specific PARP inhibitors that are now available in clinical practice.

The aim of this Special Issue is to offer an up-to-date overview of the current developments in the PARP arena and contribute with new original results.

Prof. Dr. Péter Bay
Dr. José Yélamos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.